The Y46D Mutation Destabilizes Dense Packing of the Second Greek Key Pair of Human γC-Crystallin Causing Congenital Nuclear Cataracts.
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DOI: 10.1021/acs.biochem.2c00628
Abstract: The γ-crystallins are highly expressed structural lens proteins comprising four Greek key motifs arranged in two domains. Their globular structure and short-range spatial ordering are essential for lens transparency. Aromatic residues play a vital role… read more here.
Keywords: y46d mutation; crystallin; greek key; spectroscopy ... See more keywords