Gremlin-1 is a key regulator of endothelial-to-mesenchymal transition in human pulmonary artery endothelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111941
Abstract: BACKGROUND Endothelial-to-mesenchymal transition (EndMT) has been implicated in initiation and progression of pulmonary arterial hypertension (PAH). Gremlin-1 promotes vascular remodeling of PAH and mediates epithelial-mesenchymal transition, which is similar to EndMT. In the present study… read more here.
Keywords: mesenchymal transition; endothelial mesenchymal; gremlin; pulmonary artery ... See more keywords
Gremlin is a potential target for posterior capsular opacification
Sign Up to like & getrecommendations! Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1632125
Abstract: ABSTRACT Objective: The present study was conducted to determine the role of gremlin during the development of posterior capsular opacification (PCO) via in vitro and in vivo experiments. Methods: The activation, roles and relationships of… read more here.
Keywords: pco; posterior capsular; capsular opacification; expression ... See more keywords
Gremlin in the Vitreous of Patients with Proliferative Diabetic Retinopathy and the Downregulation of Gremlin in Retinal Pigment Epithelial Cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Diabetes Research"
DOI: 10.1155/2020/9238742
Abstract: Diabetic retinopathy (DR) is one of the most common causes of blindness globally. Proliferative DR (PDR), an advanced stage of DR, is characterized by the formation of fibrotic membranes at the vitreoretinal interface. The proliferation,… read more here.
Keywords: diabetic retinopathy; pigment epithelial; rpe cells; gremlin ... See more keywords
Relationship of Plasma Gremlin 1 Levels with Body Adiposity and Glycemic Control in Saudi Female Type 2 Diabetes Patients
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s372146
Abstract: Objective Gremlin 1 is a novel adipokine that plays an important role in obesity and type 2 diabetes mellitus (T2DM). In the current study, we aimed to evaluate plasma levels of Gremlin 1 in diabetic… read more here.
Keywords: gremlin; plasma gremlin; control; type diabetes ... See more keywords
Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.681061
Abstract: Objective Systemic Sclerosis is an autoimmune connective tissue disease which results in fibrosis of the skin and lungs. The disease is characterized by activation of myofibroblasts but what governs this is unknown. Gremlin-1 is a… read more here.
Keywords: protein; systemic sclerosis; gremlin; myofibroblast transition ... See more keywords
Insights into the Role of Gremlin-1, a Bone Morphogenic Protein Antagonist, in Cancer Initiation and Progression
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020301
Abstract: The bone morphogenic protein (BMP) antagonist Gremlin-1 is a biologically significant regulator known for its crucial role in tissue differentiation and embryonic development. Nevertheless, it has been reported that Gremlin-1 can exhibit its function through… read more here.
Keywords: morphogenic protein; gremlin; role; initiation progression ... See more keywords
Production and Biochemical Characterization of Dimeric Recombinant Gremlin-1
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031151
Abstract: Gremlin-1 is a secreted cystine-knot protein that acts as an antagonist of bone morphogenetic proteins (BMPs), and as a ligand of heparin and the vascular endothelial growth factor receptor 2 (VEGFR2), thus regulating several physiological… read more here.
Keywords: production biochemical; gremlin; characterization dimeric; biochemical characterization ... See more keywords
Overexpression of Gremlin 1 by sonic hedgehog signaling promotes pancreatic cancer progression
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Oncology"
DOI: 10.3892/ijo.2018.4573
Abstract: Sonic hedgehog (SHH) signaling is an important promotor of desmoplasia, a critical feature in pancreatic cancer stromal reactions involving the activation of pancreatic stellate cells (PSCs). Gremlin 1 is widely overexpressed in cancer-associated stromal cells,… read more here.
Keywords: overexpression gremlin; pancreatic cancer; expression; shh ... See more keywords
Decreased BMP-7 and p-Smad1/5/8 expression, and increased levels of gremlin in hepatocellular carcinoma
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DOI: 10.3892/ol.2018.8918
Abstract: The aim of the present study was to investigate the expression of bone morphogenetic protein-7 (BMP-7), gremlin, and p-Smad/1/5/8 in carcinomatous and para-carcinoma tissue specimens from patients with hepatocellular carcinoma (HCC). The association of serum… read more here.
Keywords: bmp smad1; carcinoma; hcc; expression ... See more keywords