Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01569-2
Abstract: The glucocorticoid (GC) receptor (GR) suppresses inflammation by activating anti-inflammatory and repressing pro-inflammatory genes. GR-interacting protein-1 (GRIP1) is a GR corepressor in macrophages, however, whether GRIP1 mediates GR-activated transcription, and what dictates its coactivator versus… read more here.
Keywords: anti inflammatory; cdk9; inflammatory genes; grip1 ... See more keywords
Getting a GRIP on AMPARs
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.370.6513.183-e
Abstract: Neuroscience Regulation of synaptic AMPA receptors (AMPARs) is a key process implicated in synaptic plasticity. Glutamate receptor interacting protein 1 (GRIP1) is a scaffolding protein that interacts directly with several members of the AMPAR family.… read more here.
Keywords: grip1; grip ampars; getting grip;
GLCCI1 Deficiency Induces Glucocorticoid Resistance via the Competitive Binding of IRF1:GRIP1 and IRF3:GRIP1 in Asthma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.686493
Abstract: GLCCI1 plays a significant role in modulating glucocorticoid (GC) sensitivity in asthma. This project determines the underlying mechanism that GLCCI1 deficiency attenuates GC sensitivity in dexamethasone (Dex)-treated Ovalbumin (OVA)-induced asthma mice and epithelial cells through… read more here.
Keywords: grip1 irf3; glcci1 deficiency; irf3; grip1 ... See more keywords
Glutamate receptor-interacting protein 1 in D1- and D2-dopamine receptor-expressing medium spiny neurons differentially regulates cocaine acquisition, reinstatement, and associated spine plasticity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.979078
Abstract: Background The nucleus accumbens (NAc) is involved in the expression of cocaine addictive phenotypes, including acquisition, extinction, and reinstatement. In the NAc, D1-medium spiny neurons (MSNs) encode cocaine reward, whereas D2-MSNs encode aversive responses in… read more here.
Keywords: reinstatement; acquisition reinstatement; grip1; cocaine acquisition ... See more keywords