GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism
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DOI: 10.1038/s42003-024-06490-1
Abstract: G protein-coupled receptors (GPCRs) are mainly regulated by GPCR kinase (GRK) phosphorylation and subsequent β-arrestin recruitment. The ubiquitously expressed GRKs are classified into cytosolic GRK2/3 and membrane-tethered GRK5/6 subfamilies. GRK2/3 interact with activated G protein… read more here.
Keywords: grk2; biased agonism; arrestin biased; grk specificity ... See more keywords