Cell therapy rescues aging-induced beta-1 adrenergic receptor and GRK2 dysfunction in the coronary microcirculation.
Sign Up to like & getrecommendations! Published in 2021 at "GeroScience"
DOI: 10.1007/s11357-021-00455-6
Abstract: Our past study showed that coronary arterioles isolated from adipose-derived stromal vascular fraction (SVF)-treated rats showed amelioration of the age-related decrease in vasodilation to beta-adrenergic receptor (β-AR) agonist and improved β-AR-dependent coronary flow and microvascular… read more here.
Keywords: vasodilation; grk2; svf; receptor ... See more keywords
G protein-coupled receptor kinase 2 contributes to impaired fatty acid metabolism in the failing heart.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2018.08.025
Abstract: Increased G protein-coupled receptor kinase (GRK)2 is central to heart failure (HF) pathogenesis, via desensitization of β-adrenergic receptors and loss of contractile reserve. Since GRK2 has been shown to compromise fatty acid (FA) oxidation, this… read more here.
Keywords: heart; kinase; grk2; protein coupled ... See more keywords
A peptide of the amino-terminus of GRK2 induces hypertrophy and yet elicits cardioprotection after pressure overload.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2021.01.004
Abstract: G protein-coupled receptor (GPCR) kinase 2 (GRK2) expression and activity are elevated early on in response to several forms of cardiovascular stress and are a hallmark of heart failure. Interestingly, though, in addition to its… read more here.
Keywords: arknt mice; stress; pressure overload; grk2 ... See more keywords
GRK2 Dictates a Functional Switch of the Peripheral Mu-Opioid Receptor.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00622
Abstract: The peripheral mu-opioid receptor (MOR) has been recognized as a potential target to provide safer analgesia with reduced central side effects. Although analgesic incompetence of the peripheral MOR in the absence of inflammation was initially… read more here.
Keywords: peripheral opioid; opioid receptor; mor; kinase ... See more keywords
Is GRK2 a new target for cardiovascular disease?
Sign Up to like & getrecommendations! Published in 2018 at "Hypertension Research"
DOI: 10.1038/s41440-018-0052-2
Abstract: Recently, many reports have indicated that G protein, G protein-coupled receptors (GPCR), and related enzymes play an important role in cardiovascular disease. GPCR are also known as seven-(pass)-transmembrane domain receptors that are coupled with G… read more here.
Keywords: protein; insulin; grk2; target ... See more keywords
GRK2 contributes to glucose mediated calcium responses and insulin secretion in pancreatic islet cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-90253-z
Abstract: Diabetes is a metabolic syndrome rooted in impaired insulin and/or glucagon secretory responses within the pancreatic islets of Langerhans (islets). Insulin secretion is primarily regulated by two key factors: glucose-mediated ATP production and G-protein coupled… read more here.
Keywords: secretion; insulin secretion; glucose mediated; grk2 ... See more keywords
GRK2 differentially regulates FcεRI and MRGPRB2-mediated responses in mast cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1155777
Abstract: In addition to high-affinity IgE receptor (FcεRI), a subtype of mouse mast cells (MCs) expresses a G protein-coupled receptor known as Mas-related G protein-coupled receptor (GPCR)-B2 (MRGPRB2; human ortholog MRGPRX2). GPCR kinase 2 (GRK2) is… read more here.
Keywords: differentially regulates; mediated responses; ige mediated; mast cells ... See more keywords
Sensitization of the Angiotensin II AT1 Receptor Contributes to RKIP-Induced Symptoms of Heart Failure
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2018.00359
Abstract: Inhibition of the G-protein-coupled receptor kinase 2 (GRK2) is an emerging treatment approach for heart failure. Therefore, cardio-protective mechanisms induced by GRK2 inhibition are under investigation. We compared two different GRK2 inhibitors, i.e., (i) the… read more here.
Keywords: heart; rkip; grk2; heart failure ... See more keywords
GRK2-Dependent HuR Phosphorylation Regulates HIF1α Activation under Hypoxia or Adrenergic Stress
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12051216
Abstract: Adaptation to hypoxia is a common feature in solid tumors orchestrated by oxygen-dependent and independent upregulation of the hypoxia-inducible factor-1α (HIF-1α). We unveiled that G protein-coupled receptor kinase (GRK2), known to be overexpressed in certain… read more here.
Keywords: hif; hur; grk2; hypoxia ... See more keywords
GRK2 Mediates Macrophage Polarization by Regulating EP4-cAMP-pCREB Signaling in Ulcerative Colitis and the Therapeutic Effect of Paroxetine on Mice with DSS-Induced Colitis
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16050664
Abstract: G protein-coupled receptor kinase 2 (GRK2) is one of the cytosolic enzymes, and GRK2 translocation induces prostaglandin E2 receptor 4 (EP4) over-desensitization and reduces the level of cyclic adenosine monophosphate (cAMP) to regulate macrophage polarization.… read more here.
Keywords: macrophage polarization; induced colitis; dss induced; colitis ... See more keywords
Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.58442
Abstract: G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins. Different agonists can promote differential receptor-induced signaling responses – termed bias – potentially by eliciting different levels of recruitment… read more here.
Keywords: acetylcholine receptor; muscarinic acetylcholine; recruitment; grk2 ... See more keywords