Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.03.047
Abstract: The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling. While a structural understanding of GPCR/G-protein and GPCR/arrestin complexes has emerged in recent… read more here.
Keywords: grk5; structural functional; receptor; adrenergic receptor ... See more keywords
Fungal alkaloid malbrancheamide reorients the lipid binding domain of GRK5
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2024.2333987
Abstract: Abstract G protein-coupled receptors (GPCRs) are the largest group of receptors involved in various types of signaling. GPCR signaling is regulated via receptor phosphorylation by G protein-coupled receptor kinases 5 (GRK5). Calmodulin (CaM), a universal… read more here.
Keywords: grk5; phosphorylation; binding domain; malbrancheamide ... See more keywords