Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma.
Sign Up to like & getrecommendations! Published in 2021 at "Protein expression and purification"
DOI: 10.1016/j.pep.2021.105890
Abstract: Human G-protein coupled receptor kinase 6 (GRK6) belongs to the GRK4 kinase subfamily of the G protein-coupled receptor kinase family which comprises of GRK1, GRK2, and GRK4. These kinases phosphorylate ligand-activated G-protein coupled receptors (GPCRs),… read more here.
Keywords: protein; myeloma; kinase; protein coupled ... See more keywords
Downregulation of GRK6 in arcuate nucleus promotes chronic visceral hypersensitivity via NF-κB upregulation in adult rats with neonatal maternal deprivation
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DOI: 10.1177/1744806920930858
Abstract: Aims The arcuate nucleus is a vital brain region for coursing of pain command. G protein-coupled kinase 6 (GRK6) accommodates signaling through G protein-coupled receptors. Studies have demonstrated that GRK6 is involved in inflammatory pain… read more here.
Keywords: maternal deprivation; arcuate nucleus; grk6; neonatal maternal ... See more keywords
GRK6 Depletion Induces HIF Activity in Lung Adenocarcinoma
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DOI: 10.3389/fonc.2021.654812
Abstract: G protein-coupled receptor kinase 6 (GRK6) is expressed in various tissues and is involved in the development of several diseases including lung cancer. We previously reported that GRK6 is down-regulated in lung adenocarcinoma patients, which… read more here.
Keywords: lung adenocarcinoma; grk6; activity; depletion ... See more keywords
Role of GRK6 in the Regulation of Platelet Activation through Selective G Protein-Coupled Receptor (GPCR) Desensitization
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DOI: 10.3390/ijms21113932
Abstract: Platelet G protein-coupled receptors (GPCRs) regulate platelet function by mediating the response to various agonists, including adenosine diphosphate (ADP), thromboxane A2, and thrombin. Although GPCR kinases (GRKs) are considered to have the crucial roles in… read more here.
Keywords: grk6 platelets; grk6; gpcr desensitization; platelet ... See more keywords