Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia
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DOI: 10.1093/brain/awx060
Abstract: Loss-of-function mutations in progranulin (GRN), a secreted glycoprotein expressed by neurons and microglia, are a common autosomal dominant cause of frontotemporal dementia, a neurodegenerative disease commonly characterized by disrupted social and emotional behaviour. GRN mutations… read more here.
Keywords: neuronal progranulin; frontotemporal dementia; model frontotemporal; progranulin ... See more keywords