High mobility group box 1 as a biomarker in critically ill patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22584
Abstract: Extracellular release of high mobility group box 1 (HMGB1) acts as a danger‐associated molecular pattern, thereby “alarming” the immune system and promoting systemic inflammation. We investigated plasma HMGB1 concentrations as a potential diagnostic and prognostic… read more here.
Keywords: mobility group; group box; high mobility;
High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.10.008
Abstract: Approximately 30% of epilepsy patients experience seizures that are not controlled by the available drugs. Moreover, these drugs provide mainly a symptomatic treatment since they do not interfere with the disease's mechanisms. A mechanistic approach… read more here.
Keywords: high mobility; group box; mobility group; brain ... See more keywords
Histidine-Rich Glycoprotein Inhibits High-Mobility Group Box-1-Mediated Pathways in Vascular Endothelial Cells through CLEC-1A
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101180
Abstract: Summary High-mobility group box-1 (HMGB1) protein has been postulated to play a pathogenic role in severe sepsis. Histidine-rich glycoprotein (HRG), a 75 kDa plasma protein, was demonstrated to improve the survival rate of septic mice… read more here.
Keywords: hmgb1; high mobility; group box; endothelial cells ... See more keywords
High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in immunology"
DOI: 10.1016/j.smim.2018.02.011
Abstract: Alarmins are preformed, endogenous molecules that can be promptly released to signal cell or tissue stress or damage. The ubiquitous nuclear molecule high-mobility group box 1 protein (HMGB1) is a prototypical alarmin activating innate immunity.… read more here.
Keywords: hmgb1; protein; high mobility; group box ... See more keywords
HMGB1 signaling-regulated endoplasmic reticulum stress mediates intestinal ischemia/reperfusion-induced acute renal damage.
Sign Up to like & getrecommendations! Published in 2021 at "Surgery"
DOI: 10.1016/j.surg.2021.01.042
Abstract: BACKGROUND Ischemia/reperfusion of the intestine often leads to distant organ injury, but the mechanism of intestinal ischemia/reperfusion-induced renal dysfunction is still not clear. The present study aimed to investigate the mechanisms of acute renal damage… read more here.
Keywords: reperfusion; mobility group; group box; high mobility ... See more keywords
Characterization and Quantification of Oxidized High Mobility Group Box 1 Proteoforms Secreted from Hepatocytes by Toxic Levels of Acetaminophen
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Research in Toxicology"
DOI: 10.1021/acs.chemrestox.2c00161
Abstract: The high mobility group box 1 (HMGB1), which is released during acute acetaminophen (APAP) overdose, is thought to mediate a subsequent immune response, particularly hepatic infiltration of macrophages. The redox behavior of HMGB1 and the… read more here.
Keywords: disulfide; mobility group; group box; cys ... See more keywords
Cross-Talk between Sirtuin 1 and the Proinflammatory Mediator High-Mobility Group Box-1 in the Regulation of Blood-Retinal Barrier Breakdown in Diabetic Retinopathy
Sign Up to like & getrecommendations! Published in 2019 at "Current Eye Research"
DOI: 10.1080/02713683.2019.1625406
Abstract: ABSTRACT Purpose: High-mobility group box-1 (HMGB1) mediates inflammation and breakdown of blood-retinal barrier (BRB) in diabetic retina. Sirtuin-1 (SIRT1) has protective effects against inflammation and oxidative stress. The aim of this study was to investigate… read more here.
Keywords: hmgb1; sirt1; high mobility; group box ... See more keywords
Novel understanding of high mobility group box-1 in the immunopathogenesis of incisional hernias
Sign Up to like & getrecommendations! Published in 2019 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2019.1608822
Abstract: ABSTRACT Introduction: Incisional hernias (IH) arise as a complication of patients undergoing laparotomy. Current literature has assessed the role of extracellular matrix (ECM) disorganization, alterations in type I and type III collagen, matrix metalloproteinases, and… read more here.
Keywords: disorganization; mobility group; ecm disorganization; high mobility ... See more keywords
Systemic High-Mobility Group Box-1: A Novel Predictive Biomarker for Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage*
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000003319
Abstract: Objectives: To investigate the release of proinflammatory damage-associated molecular pattern molecule “high-mobility group box-1” in the serum of patients after aneurysmal subarachnoid hemorrhage and its association with cerebral vasospasm. Design: Retrospective observational study. Setting: University… read more here.
Keywords: hemorrhage; mobility group; group box; high mobility ... See more keywords
High‐mobility group box 1 is a driver of inflammation throughout pregnancy
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13328
Abstract: A proinflammatory response driven by high‐mobility group box 1 (HMGB1) is important for the success of both the early stages of pregnancy and parturition initiation. However, the tight regulation of HMGB1 within these two stages… read more here.
Keywords: hmgb1; pregnancy; high mobility; group box ... See more keywords
Ethyl pyruvate attenuates ventilation‐induced diaphragm dysfunction through high‐mobility group box‐1 in a murine endotoxaemia model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14478
Abstract: Mechanical ventilation (MV) can save the lives of patients with sepsis. However, MV in both animal and human studies has resulted in ventilator‐induced diaphragm dysfunction (VIDD). Sepsis may promote skeletal muscle atrophy in critically ill… read more here.
Keywords: hmgb1; high mobility; group box; diaphragm dysfunction ... See more keywords