Dualistic Roles of High Mobility Group Box 1 in Cancer and Inflammation
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Medicine"
DOI: 10.1002/cam4.71455
Abstract: The High Mobility Group Box 1 (HMGB1) protein, a member of the HMG family, plays a crucial role in both cancer progression and inflammatory responses. HMGB1 can act as a damage‐associated molecular pattern (DAMP) to… read more here.
Keywords: cancer; group box; mobility group; dualistic roles ... See more keywords
High mobility group box 1 as a biomarker in critically ill patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22584
Abstract: Extracellular release of high mobility group box 1 (HMGB1) acts as a danger‐associated molecular pattern, thereby “alarming” the immune system and promoting systemic inflammation. We investigated plasma HMGB1 concentrations as a potential diagnostic and prognostic… read more here.
Keywords: mobility group; group box; high mobility;
High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.10.008
Abstract: Approximately 30% of epilepsy patients experience seizures that are not controlled by the available drugs. Moreover, these drugs provide mainly a symptomatic treatment since they do not interfere with the disease's mechanisms. A mechanistic approach… read more here.
Keywords: high mobility; group box; mobility group; brain ... See more keywords
Histidine-Rich Glycoprotein Inhibits High-Mobility Group Box-1-Mediated Pathways in Vascular Endothelial Cells through CLEC-1A
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101180
Abstract: Summary High-mobility group box-1 (HMGB1) protein has been postulated to play a pathogenic role in severe sepsis. Histidine-rich glycoprotein (HRG), a 75 kDa plasma protein, was demonstrated to improve the survival rate of septic mice… read more here.
Keywords: hmgb1; high mobility; group box; endothelial cells ... See more keywords
High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in immunology"
DOI: 10.1016/j.smim.2018.02.011
Abstract: Alarmins are preformed, endogenous molecules that can be promptly released to signal cell or tissue stress or damage. The ubiquitous nuclear molecule high-mobility group box 1 protein (HMGB1) is a prototypical alarmin activating innate immunity.… read more here.
Keywords: hmgb1; protein; high mobility; group box ... See more keywords
HMGB1 signaling-regulated endoplasmic reticulum stress mediates intestinal ischemia/reperfusion-induced acute renal damage.
Sign Up to like & getrecommendations! Published in 2021 at "Surgery"
DOI: 10.1016/j.surg.2021.01.042
Abstract: BACKGROUND Ischemia/reperfusion of the intestine often leads to distant organ injury, but the mechanism of intestinal ischemia/reperfusion-induced renal dysfunction is still not clear. The present study aimed to investigate the mechanisms of acute renal damage… read more here.
Keywords: reperfusion; mobility group; group box; high mobility ... See more keywords
Characterization and Quantification of Oxidized High Mobility Group Box 1 Proteoforms Secreted from Hepatocytes by Toxic Levels of Acetaminophen
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Research in Toxicology"
DOI: 10.1021/acs.chemrestox.2c00161
Abstract: The high mobility group box 1 (HMGB1), which is released during acute acetaminophen (APAP) overdose, is thought to mediate a subsequent immune response, particularly hepatic infiltration of macrophages. The redox behavior of HMGB1 and the… read more here.
Keywords: disulfide; mobility group; group box; cys ... See more keywords
A Glycyrrhizin Derivative with a More Potent Inhibitory Activity against High-Mobility Group Box 1 Efficiently Discovered by Chemical Synthesis Inspired by the Bioconversion Products of an Endophytic Fungus Isolated from Licorice.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c01213
Abstract: Glycyrrhizin (GL) from licorice alleviates intracerebral hemorrhage (ICH) injuries by interacting with high-mobility group box (HMGB) 1, an inflammatory factor. We found that GL is bioconverted by endophyte coexisting with licorice and succeeded in isolating… read more here.
Keywords: group box; mobility group; inhibitory activity; high mobility ... See more keywords
Cross-Talk between Sirtuin 1 and the Proinflammatory Mediator High-Mobility Group Box-1 in the Regulation of Blood-Retinal Barrier Breakdown in Diabetic Retinopathy
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DOI: 10.1080/02713683.2019.1625406
Abstract: ABSTRACT Purpose: High-mobility group box-1 (HMGB1) mediates inflammation and breakdown of blood-retinal barrier (BRB) in diabetic retina. Sirtuin-1 (SIRT1) has protective effects against inflammation and oxidative stress. The aim of this study was to investigate… read more here.
Keywords: hmgb1; sirt1; high mobility; group box ... See more keywords
Novel understanding of high mobility group box-1 in the immunopathogenesis of incisional hernias
Sign Up to like & getrecommendations! Published in 2019 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2019.1608822
Abstract: ABSTRACT Introduction: Incisional hernias (IH) arise as a complication of patients undergoing laparotomy. Current literature has assessed the role of extracellular matrix (ECM) disorganization, alterations in type I and type III collagen, matrix metalloproteinases, and… read more here.
Keywords: disorganization; mobility group; ecm disorganization; high mobility ... See more keywords
Systemic High-Mobility Group Box-1: A Novel Predictive Biomarker for Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage*
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000003319
Abstract: Objectives: To investigate the release of proinflammatory damage-associated molecular pattern molecule “high-mobility group box-1” in the serum of patients after aneurysmal subarachnoid hemorrhage and its association with cerebral vasospasm. Design: Retrospective observational study. Setting: University… read more here.
Keywords: hemorrhage; mobility group; group box; high mobility ... See more keywords