Highly Chemoselective Ni-Catalyzed Protecting-Group-Free 2,2'-Biphenol Synthesis and Mechanistic Insights.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01367
Abstract: The utilization of readily available starting materials to produce useful molecules is often challenged by selectivity issues. In this study, a Ni-catalyzed protecting-group-free C-C coupling protocol is described for the efficient synthesis of 2,2'-biphenol derivatives.… read more here.
Keywords: catalyzed protecting; biphenol; group free; synthesis ... See more keywords
Metal and Activating Group Free C-4 Alkylation of Isoquinolines via a Temporary Dearomatization Strategy
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DOI: 10.1021/acs.orglett.2c04149
Abstract: A simple method for the C-4 alkylation of isoquinolines is described using benzoic acid as a nucleophilic reagent and vinyl ketones as an electrophile. The reaction shows tolerance for substitution at C-3, and C-5–C-8 positions… read more here.
Keywords: activating group; group free; alkylation; metal activating ... See more keywords
Innovation in protecting-group-free natural product synthesis
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DOI: 10.1038/s41570-018-0071-1
Abstract: Many natural products have intriguing medicinal properties that arise from their fascinating chemical structures. This structural complexity means that the total synthesis of natural products often requires the use of protecting-group chemistry, an approach that… read more here.
Keywords: natural products; protecting group; chemistry; synthesis ... See more keywords
A Free-Radical and Protecting-Group-Free Approach to (–)-Boschnialactone and γ-Lycorane
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DOI: 10.1055/s-0037-1612248
Abstract: The protecting-group-free (PGF) and free-radical-based synthesis of two structurally different natural products, (–)-boschnialactone and γ-lycorane, is reported. The key step in both syntheses is a radical–ionic sequence for construction of the principal structure (a six-membered… read more here.
Keywords: group free; protecting group; free radical; boschnialactone lycorane ... See more keywords
Short Protecting Group-free Syntheses of CDE Synthon of Racemic Camptothecin.
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DOI: 10.2174/1570179417666200611125740
Abstract: A practical and concise total synthesis of tricyclic ketone 7 (CDE ring), a valuable intermediate for the synthesis of racemic camptothecin and analogs, was described (8 chemical steps and 29% overall yield). The synthesis starts… read more here.
Keywords: protecting group; racemic camptothecin; synthesis; group free ... See more keywords