Directing Group Guided Site-Selective Diversification of Indoles by Aziridine: Synthesis of β-Indolylethylamines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00120
Abstract: A palladium catalyzed directing group assisted cross-coupling of aliphatic aziridines with indole, indoline, tetrahydroquinoline, and aniline has been developed to furnish the corresponding β-arylethylamine derivatives. The substrate scope was very general, and the protocol was… read more here.
Keywords: guided site; site selective; group; selective diversification ... See more keywords
A functional group–guided approach to aptamers for small molecules
Sign Up to like & getrecommendations! Published in 2023 at "Science"
DOI: 10.1126/science.abn9859
Abstract: Aptameric receptors are important biosensor components, yet our ability to identify them depends on the target structures. We analyzed the contributions of individual functional groups on small molecules to binding within 27 target-aptamer pairs, identifying… read more here.
Keywords: aptamers small; small molecules; group guided; functional group ... See more keywords