Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils
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DOI: 10.1002/advs.202206958
Abstract: Development of abdominal aortic aneurysms (AAA) enhances lesion group‐2 innate lymphoid cell (ILC2) accumulation and blood IL5. ILC2 deficiency in Rorafl/flIl7rCre/+ mice or induced ILC2 depletion in Icosfl‐DTR‐fl/+Cd4Cre/+ mice expedites AAA growth, increases lesion inflammation,… read more here.
Keywords: il5; ilc2; via il5; abdominal aortic ... See more keywords
Reduced numbers of circulating group 2 innate lymphoid cells in patients with common variable immunodeficiency
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201746961
Abstract: Recent studies identified an emerging role of group 2 and 3 innate lymphoid cells (ILCs) as key players in the generation of T‐dependent and T‐independent antibody production. In this retrospective case‐control study, CD117+ ILCs (including… read more here.
Keywords: ilc2; reduction; patients common; group innate ... See more keywords
Group‐2 Innate Lymphoid Cells Promote HCC Progression Through CXCL2‐Neutrophil‐Induced Immunosuppression
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.31855
Abstract: Due to their inherent characteristics, the function of group‐2 innate lymphoid cells (ILC2s) varies in a context‐dependent manner. ILC2s are involved in certain liver diseases; however, their involvement in HCC is unknown. In the present… read more here.
Keywords: cells promote; group innate; innate lymphoid; lymphoid cells ... See more keywords
Identification and Functional Characterization of Murine Group 3 Innate Lymphoid Cell (ILC3) Subsets in the Intestinal Tract and Associated Lymphoid Tissues.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0338-3_4
Abstract: Group 3 innate lymphoid cells (ILC3s) are critical mediators of innate immune responses at mucosal barriers in both health and disease. ILC3s rapidly respond to environmental cues to reinforce barrier function and foster a mutualistic… read more here.
Keywords: tract associated; innate lymphoid; group innate; biology ... See more keywords
Activations of group 2 innate lymphoid cells depend on endotypes of chronic rhinosinusitis
Sign Up to like & getrecommendations! Published in 2018 at "European Archives of Oto-Rhino-Laryngology"
DOI: 10.1007/s00405-018-5180-4
Abstract: ObjectiveChronic rhinosinusitis (CRS) is a complicated disease with several variants caused by different cellular and molecular mechanisms. The characterization of this heterogeneity supports the definition that the disease consists of many endotypes, such as eosinophilic… read more here.
Keywords: rhinosinusitis; group innate; innate lymphoid; lymphoid cells ... See more keywords
The Neuropeptide CGRP Induces Bipolar Syndrome in Group 2 Innate Lymphoid Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.09.015
Abstract: In this issue of Immunity, Nagashima et al., Wallrapp et al., and Xu et al. demonstrate that the neuropeptide calcitonin gene-related peptide (CGRP) fine tunes type 2 innate immune response via suppressing group 2 innate lymphoid cells (ILC2s). read more here.
Keywords: innate lymphoid; group innate; lymphoid cells;
Group 1 innate lymphoid-cell-derived interferon-γ maintains anti-viral vigilance in the mucosal epithelium.
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2020.12.004
Abstract: The oropharyngeal mucosa serves as a perpetual pathogen entry point and a critical site for viral replication and spread. Here, we demonstrate that type 1 innate lymphoid cells (ILC1s) were the major immune force providing… read more here.
Keywords: cell derived; group innate; mucosal; innate lymphoid ... See more keywords
Activation and Suppression of Group 3 Innate Lymphoid Cells in the Gut.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in immunology"
DOI: 10.1016/j.it.2020.06.009
Abstract: Group 3 innate lymphoid cells (ILC3s) have emerged as master regulators of intestinal health and tissue homeostasis in mammals. Through a diverse array of cytokines and cellular interactions, ILC3s crucially orchestrate lymphoid organogenesis, promote tissue… read more here.
Keywords: innate lymphoid; group innate; activation suppression; lymphoid cells ... See more keywords
Pulmonary group 2 innate lymphoid cells: surprises and challenges
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DOI: 10.1038/s41385-018-0130-4
Abstract: Group 2 innate lymphoid cells (ILC2s) are a recently described subset of innate lymphocytes with important immune and homeostatic functions at multiple tissue sites, especially the lung. These cells expand locally after birth and during… read more here.
Keywords: innate; innate lymphoid; group innate; lymphoid cells ... See more keywords
Enteric bacteria induce IFNγ and Granzyme B from human colonic Group 1 Innate Lymphoid Cells
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DOI: 10.1080/19490976.2019.1667723
Abstract: ABSTRACT Group 1 Innate Lymphoid Cells (which include Natural Killer cells and ILC1s) aid in gut anti-bacterial defense through the production of IFNγ, which is critical for mobilizing protective responses against enteric pathogens. When intestinal… read more here.
Keywords: production; commensal; group innate; group ... See more keywords
Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvac144
Abstract: Abstract Aims Group 2 innate lymphoid cells (ILC2s) regulate adaptive and innate immunities. In mouse heart, production of myocardial infarction (MI) increased ILC2 accumulation, suggesting a role for ILC2 in cardiac dysfunction post-MI. Methods and… read more here.
Keywords: il5; ilc2; group innate; mice ... See more keywords