Structure determination of group II introns.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2017.06.020
Abstract: Group II introns are self-splicing catalytic RNAs that are able to excise themselves from pre-mRNAs using a mechanism identical to that utilized by the spliceosome. Both structural and phylogenetic data support the hypothesis that group… read more here.
Keywords: structure determination; determination group; group introns; group ... See more keywords
Small molecules that target group II introns are potent antifungal agents
Sign Up to like & getrecommendations! Published in 2018 at "Nature chemical biology"
DOI: 10.1038/s41589-018-0142-0
Abstract: Specific RNA structures control numerous metabolic processes that impact human health, and yet efforts to target RNA structures de novo have been limited. In eukaryotes, the self-splicing group II intron is a mitochondrial RNA tertiary… read more here.
Keywords: target group; molecules target; small molecules; group ... See more keywords
Discovery of highly reactive self-splicing group II introns within the mitochondrial genomes of human pathogenic fungi
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1077
Abstract: Abstract Fungal pathogens represent an expanding global health threat for which treatment options are limited. Self-splicing group II introns have emerged as promising drug targets, but their development has been limited by a lack of… read more here.
Keywords: group; self splicing; group introns; splicing group ... See more keywords
Origin and evolution of chloroplast group I introns in lichen algae
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Phycology"
DOI: 10.1111/jpy.12600
Abstract: The history of group I introns is characterized by repeated horizontal transfers, even among phylogenetically distant species. The symbiogenetic thalli of lichens are good candidates for the horizontal transfer of genetic material among distantly related… read more here.
Keywords: algae; chloroplast; group introns; group ... See more keywords
Group II Introns: Highly Structured yet Dynamic
Sign Up to like & getrecommendations! Published in 2023 at "CHIMIA"
DOI: 10.2533/chimia.2023.235
Abstract: RNA splicing, the removal of introns and ligation of exons, is a crucial process during mRNA maturation. Group II introns are large ribozymes that self-catalyze their splicing, as well as their transposition. They are living… read more here.
Keywords: highly structured; yet dynamic; introns highly; structured yet ... See more keywords
Polymorphism in Mitochondrial Group I Introns among Cryptococcus neoformans and Cryptococcus gattii Genotypes and Its Association with Drug Susceptibility
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.00086
Abstract: Cryptococcosis, one of the most important systemic mycosis in the world, is caused by different genotypes of Cryptococcus neoformans and Cryptococcus gattii, which differ in their ecology, epidemiology, and antifungal susceptibility. Therefore, the search for… read more here.
Keywords: cryptococcus neoformans; group introns; susceptibility; drug susceptibility ... See more keywords
Contribution of Mobile Group II Introns to Sinorhizobium meliloti Genome Evolution
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.00627
Abstract: Mobile group II introns are ribozymes and retroelements that probably originate from bacteria. Sinorhizobium meliloti, the nitrogen-fixing endosymbiont of legumes of genus Medicago, harbors a large number of these retroelements. One of these elements, RmInt1,… read more here.
Keywords: meliloti genome; evolution; mobile group; group introns ... See more keywords
Distinct Expansion of Group II Introns During Evolution of Prokaryotes and Possible Factors Involved in Its Regulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.849080
Abstract: Group II introns (G2Is) are ribozymes that have retroelement characteristics in prokaryotes. Although G2Is are suggested to have been an important evolutionary factor in the prokaryote-to-eukaryote transition, comprehensive analyses of these introns among the tens… read more here.
Keywords: group; group introns; evolution prokaryotes; expansion group ... See more keywords
Group II Introns: Flexibility and Repurposing
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.916157
Abstract: Group II introns are extraordinarily versatile self-splicing ribozymes and retrotransposable elements widespread in bacteria and in bacterial-derived organelles (mitochondria and chloroplasts) of fungi, algae, plants, and of some early-branching metazoans (Zimmerly and Semper, 2015). These… read more here.
Keywords: intron; flexibility repurposing; self splicing; group ... See more keywords
Updated Progress on Group II Intron Splicing Factors in Plant Chloroplasts
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44090290
Abstract: Group II introns are large catalytic RNAs (ribozymes) in the bacteria and organelle genomes of several lower eukaryotes. Many critical photosynthesis-related genes in the plant chloroplast genome also contain group II introns, and their splicing… read more here.
Keywords: intron; chloroplast; group; splicing factors ... See more keywords