Introducing N-Carboxyethyl-Ynamides, Precursors of Metalated Ketenimines: Protecting Group Swap in Ynamides and Olefination of Aldehydes.
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DOI: 10.1021/acs.orglett.5c03692
Abstract: N-Carboxyethyl-ynamides are shown to be useful and versatile precursors of metalated ketenimines. Upon simple treatment with a strong base, a retro-Michael addition indeed affords these highly reactive ambident electrophilic intermediates that can hardly be generated… read more here.
Keywords: group swap; precursors metalated; protecting group; carboxyethyl ynamides ... See more keywords