Modulation of growth cone filopodial length by carbon monoxide
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22430
Abstract: Carbon monoxide (CO) is physiologically produced via heme degradation by heme oxygenase enzymes. Whereas CO has been identified as an important physiological signaling molecule, the roles it plays in neuronal development and regeneration are poorly… read more here.
Keywords: growth cone; growth; carbon monoxide; filopodial length ... See more keywords
Using Rotary Shadow Electron Microscopy to Characterize Semaphorin-Mediated Growth Cone Collapse.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6448-2_13
Abstract: Rotary shadow electron microscopy (EM) of growth cone cytoskeletons provides a high-resolution method for detecting both global and macromolecular changes in cytoskeletal organization or structure. This approach can be used to study responses to repulsive… read more here.
Keywords: microscopy; shadow electron; electron microscopy; rotary shadow ... See more keywords
Differential Regulation of Neurite Outgrowth and Growth Cone Morphology by 3D Fibronectin and Fibronectin-Collagen Extracellular Matrices.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02637-x
Abstract: The extracellular matrix (ECM) plays a critical role in development, homeostasis, and regeneration of tissue structures and functions. Cell interactions with the ECM are dynamic and cells respond to ECM remodeling by changes in morphology… read more here.
Keywords: fibronectin; growth cone; matrix; growth ... See more keywords
Microtubules, actin and cytolinkers: how to connect cytoskeletons in the neuronal growth cone
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.135693
Abstract: Cytolinkers ensure the integration of the different cytoskeleton components in the neuronal growth cone during development and in the course of axon regeneration. In neurons, an integrated skeleton guarantees appropriate function, and connectivity of high… read more here.
Keywords: neuronal growth; growth cone; actin cytolinkers; microtubules actin ... See more keywords
Vinaxanthone inhibits Semaphorin3A induced axonal growth cone collapse in embryonic neurons but fails to block its growth promoting effects on adult neurons
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92375-w
Abstract: Semaphorin3A is considered a classical repellent molecule for developing neurons and a potent inhibitor of regeneration after nervous system trauma. Vinaxanthone and other Sema3A inhibitors are currently being tested as possible therapeutics to promote nervous… read more here.
Keywords: adult neurons; cone collapse; sema3a; growth cone ... See more keywords
The PH/MyTH4/FERM molecule MAX-1 inhibits UNC-5 activity in regulation of VD growth cone protrusion in Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac047
Abstract: UNC-6/Netrin is a secreted conserved guidance cue that regulates dorsal-ventral axon guidance of C. elegans and in the vertebral spinal cord. In the polarity/protrusion model of VD growth cone guidance away from ventrally-expressed UNC-6 (repulsion),… read more here.
Keywords: growth cone; protrusion; growth; guidance ... See more keywords
Growth cone macropinocytosis of neurotrophin receptor and neuritogenesis are regulated by neuron navigator 1
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1101/2022.01.31.478516
Abstract: Neuron Navigator 1 (Nav1) is a cytoskeleton-associated protein expressed during brain development that is necessary for proper neuritogenesis, but the underlying mechanisms are poorly understood. Here we show that Nav1 is present in elongating axon… read more here.
Keywords: growth cone; growth; neuron navigator; cone macropinocytosis ... See more keywords
Cannabinoid Receptor Type 1 regulates growth cone filopodia and axon dispersion in the optic tract of Xenopus laevis tadpoles
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15603
Abstract: Previous studies show that the main cannabinoid receptor in the brain—cannabinoid type 1 receptor (CB1R)—is required for establishment of axonal projections in developing neurons but questions remain regarding the cellular and molecular mechanisms, especially in… read more here.
Keywords: optic tract; growth; growth cone; cone filopodia ... See more keywords
Ultrafast laser-assisted spatially targeted optoporation into cortical axons and retinal cells in the eye.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biomedical optics"
DOI: 10.1117/1.jbo.22.6.060504
Abstract: Visualization and assessment of the cellular structure and function require localized delivery of the molecules into specific cells in restricted spatial regions of the tissue and may necessitate subcellular delivery and localization. Earlier, we have… read more here.
Keywords: optoporation; laser; retinal cells; visualization ... See more keywords
Syntaphilin-Mediated Docking of Mitochondria at the Growth Cone Is Dispensable for Axon Elongation In Vivo
Sign Up to like & getrecommendations! Published in 2019 at "eNeuro"
DOI: 10.1523/eneuro.0026-19.2019
Abstract: Abstract Mitochondria are abundantly detected at the growth cone, the dynamic distal tip of developing axons that directs growth and guidance. It is, however, poorly understood how mitochondrial dynamics relate to growth cone behavior in… read more here.
Keywords: growth; growth cone; mitochondria growth; vivo ... See more keywords
Control of Growth Cone Polarity, Microtubule Accumulation, and Protrusion by UNC-6/Netrin and Its Receptors in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2018 at "Genetics"
DOI: 10.1534/genetics.118.301234
Abstract: UNC-6/Netrin has a conserved role in dorsal-ventral axon guidance, but the cellular events in the growth cone regulated by UNC-6/Netrin signaling during outgrowth are incompletely understood. Previous studies showed that, in growth cones migrating away… read more here.
Keywords: accumulation; protrusion; growth cone; growth ... See more keywords