4PBA reduces growth deficiency in osteogenesis imperfecta by enhancing transition of hypertrophic chondrocytes to osteoblasts
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DOI: 10.1172/jci.insight.149636
Abstract: Short stature is a major skeletal phenotype in osteogenesis imperfecta (OI), a genetic disorder mainly caused by mutations in genes encoding type I collagen. However, the underlying mechanism is poorly understood, and no effective treatment… read more here.
Keywords: growth; growth deficiency; hypertrophic chondrocytes; osteogenesis imperfecta ... See more keywords