Non-Destructively Quantifying the Whole-Course Growth and Drug-Response of PDOs by an Automatic Microfluidic System Utilizing Chemiluminescence Detection.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202512951
Abstract: Patient‐derived organoids (PDOs) have become promising tools in precision medicine research. While conventional imaging techniques provide morphological assessment, they fail to reveal crucial molecular‐level changes. Monitoring secreted biomarkers presents an alternative approach that can deliver… read more here.
Keywords: response pdos; drug; growth drug; drug response ... See more keywords
iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.
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DOI: 10.1016/j.ccell.2017.09.008
Abstract: Reactive oxygen species (ROS) have emerged as important signaling molecules that play crucial roles in carcinogenesis and cytotoxic responses. Nrf2 is the master regulator of ROS balance. Thus, uncovering mechanisms of Nrf2 regulation is important… read more here.
Keywords: drug resistance; growth drug; keap1 binding; nrf2 keap1 ... See more keywords
Knockdown of long non-coding RNA PCAT-1 inhibits myeloma cell growth and drug resistance via p38 and JNK MAPK pathways
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DOI: 10.7150/jca.35098
Abstract: Objective: Both previous and recent literature showed long non-coding RNAs (lncRNAs) were crucial participants in multiple myeloma (MM) evolution. However, the dynamic regulation and mechanism of lncRNAs in MM progression was not fully understood. This… read more here.
Keywords: growth drug; long non; cell growth; non coding ... See more keywords