Glucocorticoids Decrease Longitudinal Bone Growth in Pediatric Kidney Transplant Recipients by Stimulating the FGF23/FGFR3 Signaling Pathway
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DOI: 10.1002/jbmr.3761
Abstract: Renal transplantation (RTx) is an effective therapy to improve clinical outcomes in pediatric patients with terminal chronic kidney disease. However, chronic immunosuppression with glucocorticoids (GCs) reduces bone growth and BMD. The mechanisms causing GC‐induced growth… read more here.
Keywords: fgf23; bone growth; bone; expression ... See more keywords
Growth impairment in individuals with citrin deficiency
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12051
Abstract: Citrin deficiency causes neonatal intrahepatic cholestasis (NICCD), failure to thrive and dyslipidemia (FTTDCD), and adult‐onset type II citrullinemia (CTLN2). Owing to a defect in the NADH‐shuttle, citrin deficiency impairs hepatic glycolysis and de novo lipogenesis… read more here.
Keywords: growth impairment; growth; body; citrin deficiency ... See more keywords