Polyamines interfere with protein ubiquitylation and cause depletion of intracellular amino acids: a possible mechanism for cell growth inhibition
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13299
Abstract: Spermidine is a polyamine present in eukaryotes with essential functions in protein synthesis. At high concentrations spermidine and norspermidine inhibit growth by unknown mechanisms. Transcriptomic analysis of the effect of norspermidine on the plant Arabidopsis… read more here.
Keywords: amino acids; protein ubiquitylation; growth inhibition; depletion ... See more keywords
Bacterial Growth Inhibition Screen (BGIS) identifies a loss‐of‐function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Letters"
DOI: 10.1002/1873-3468.14070
Abstract: The DEK oncoprotein regulates cellular chromatin function via a number of protein–protein interactions. However, the biological relevance of its unique pseudo‐SAP/SAP‐box domain, which transmits DNA modulating activities in vitro, remains largely speculative. As hypothesis‐driven mutations… read more here.
Keywords: dna modulating; modulating activities; dek; growth inhibition ... See more keywords
Early decision making in a randomized phase II trial of atezolizumab in biliary tract cancer using a tumor growth inhibition-survival modeling framework.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2953
Abstract: We assess the longitudinal tumor growth inhibition (TGI) metrics and overall survival (OS) predictions applied to patients with advanced biliary tract cancer (BTC) enrolled in IMbrave151 a multicenter randomized phase II, double-blind, placebo-controlled trial evaluating… read more here.
Keywords: tumor growth; trial; growth inhibition; phase ... See more keywords
Rapamycin enhances growth inhibition on urothelial carcinoma cells through LKB1 deficiency‐mediated mitochondrial dysregulation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27979
Abstract: Rapamycin, a mammalian target of rapamycin (mTOR) inhibitor, has significant potential for application in the treatment of urothelial carcinoma (URCa) of the bladder. Previous studies have shown that regulation of the AMP‐activated serine/threonine protein kinase… read more here.
Keywords: growth inhibition; urothelial carcinoma; urca cells; lkb1 deficiency ... See more keywords
The Growth-Inhibiting Effects of Beef Fatty Acids on MCF-7 Cells Are Influenced Mostly by the Depot Location and Inconsistently by the Biohydrogenation Intermediate Content.
Sign Up to like & getrecommendations! Published in 2018 at "Lipids"
DOI: 10.1002/lipd.12085
Abstract: Biohydrogenation intermediates (BHI) including conjugated linoleic acid (CLA) isomers are formed during ruminal biohydrogenation of polyunsaturated fatty acids (PUFA) in ruminants. Although many studies have examined the anticarcinogenic effects of CLA, few studies have reported… read more here.
Keywords: bhi; beef; biohydrogenation; fatty acids ... See more keywords
Identification of Genes Involved in Root Growth Inhibition Under Lead Stress by Transcriptome Profiling in Arabidopsis
Sign Up to like & getrecommendations! Published in 2020 at "Plant Molecular Biology Reporter"
DOI: 10.1007/s11105-020-01233-y
Abstract: Lead (Pb) is a heavy metal with high toxicity to plants. Root is the major organ to respond to Pb stress. However, little is known about how plant roots perceive Pb stress signaling. Here, we… read more here.
Keywords: stress; arabidopsis; root growth; growth inhibition ... See more keywords
Effect of humic acids on the toxicity of pollutants to Chlamydomonas reinhardtii: Investigation by a microscale algal growth inhibition test
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-10425-8
Abstract: Dissolved humic substances (DHSs) are the major components of organic matter in the aquatic environment. DHSs are well known to considerably affect the speciation, solubility, and toxicity of a wide variety of pollutants in the… read more here.
Keywords: algal growth; growth inhibition; toxicity; microscale algal ... See more keywords
Dichromate-induced ethylene biosynthesis, perception, and signaling regulate the variance in root growth inhibition among Shaheen basmati and basmati-385 rice varieties
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-021-13477-6
Abstract: Heavy metals, including a hexavalent form of chromium (Cr(VI)) increasing accumulation in agricultural soil, cause a significant reduction in quality, yield, and growth of rice varieties worldwide. Screening for the selection of tolerant varieties is… read more here.
Keywords: biosynthesis; inhibition; root growth; growth inhibition ... See more keywords
Algal growth inhibition test results of 425 organic chemical substances.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.04.047
Abstract: The toxicity towards the algal species Pseudokirchneriella subcapitata of 425 organic chemical substances was tested in a growth inhibition test. Precautions were taken to prevent loss of the compounds from the water phase and the… read more here.
Keywords: 425 organic; growth inhibition; chemical; organic chemical ... See more keywords
Linking phenylpropanoid metabolism, lignin deposition, and plant growth inhibition.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2018.12.008
Abstract: Lignin, a polymer found in the plant secondary cell wall, is a major contributor to biomass' recalcitrance toward saccharification. Because of this negative impact toward the value of lignocellulosic crops, there is a special interest… read more here.
Keywords: phenylpropanoid metabolism; plant; plant growth; lignin ... See more keywords
Ice crystal growth inhibition by peptides from fish gelatin hydrolysate
Sign Up to like & getrecommendations! Published in 2017 at "Food Hydrocolloids"
DOI: 10.1016/j.foodhyd.2017.03.029
Abstract: Abstract Ice crystal growth inhibition in an ice cream mix matrix and in sucrose solutions by peptides derived from alcalase (also known as subtilisin) hydrolyzed fish gelatin was investigated. Hydrolysis of fish gelatin at an… read more here.
Keywords: ice crystal; crystal growth; growth inhibition; gelatin ... See more keywords