A unifying autocatalytic network-based framework for bacterial growth laws
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2107829118
Abstract: Significance Bacterial cells contain various autocatalytic cycles, e.g., the ribosome cycle, where ribosomes translate ribosomal proteins that subsequently self-assemble to form new ribosomes. Here, we show that the transcription–translation machinery couples all cellular autocatalytic cycles,… read more here.
Keywords: autocatalytic network; cycle; rate; growth ... See more keywords
Protein degradation sets the fraction of active ribosomes at vanishing growth
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1101/2021.03.25.436692
Abstract: Growing cells adopt common basic strategies to achieve optimal resource allocation under limited resource availability. Our current understanding of such “growth laws” neglects degradation, assuming that it occurs slowly compared to the cell cycle duration.… read more here.
Keywords: growth; active ribosomes; protein degradation; growth laws ... See more keywords