Upregulation of lncRNA GAS5 inhibits the growth and metastasis of cervical cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28926
Abstract: This study aims to figure out the methylation of long non‐coding RNA GAS5 promoter in cervical cancer and the mechanism of GAS5 on the progression of cervical cancer cells. The expression of GAS5 and methylation… read more here.
Keywords: cancer cells; cervical cancer; growth metastasis; gas5 ... See more keywords
LncRNA DANCR regulates the growth and metastasis of oral squamous cell carcinoma cells via altering miR-216a-5p expression.
Sign Up to like & getrecommendations! Published in 2020 at "Human cell"
DOI: 10.1007/s13577-020-00411-0
Abstract: The study aims to investigate how DANCR can alter the growth and metastasis of oral squamous cell carcinoma (OSCC) cells by regulating miR-216a-5p. The expression of DANCR and miR-216a-5p in OSCC patients and cells were… read more here.
Keywords: mir 216a; expression; growth metastasis; dancr ... See more keywords
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
Sign Up to like & getrecommendations! Published in 2021 at "Cell metabolism"
DOI: 10.1016/j.cmet.2021.11.011
Abstract: Accelerated glycolysis is the main metabolic change observed in cancer, but the underlying molecular mechanisms and their role in cancer progression remain poorly understood. Here, we show that the deletion of the long noncoding RNA… read more here.
Keywords: cancer; growth metastasis; glycolysis; neat1 essential ... See more keywords
Extracellular vesicles extracted from bone marrow mesenchymal stem cells carrying MicroRNA-342-3p inhibit the INHBA/IL13Rα2 axis to suppress the growth and metastasis of breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101333
Abstract: Highlights • BMSC-EVs carrying miR-342-3p could prevent breast cancer growth and metastasis by downregulating the INHBA/IL13Rα2 axis, highlighting a potential target for anti-cancer treatment for breast cancer. read more here.
Keywords: cancer; breast cancer; growth metastasis; il13r axis ... See more keywords
Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00004
Abstract: Osteosarcoma is one of the most common malignant bone tumors. However, the treatment and clinical outcomes of osteosarcoma have hardly changed over the past three decades due to the comprehensive heterogeneity and higher rate of… read more here.
Keywords: metastasis; cyanothiophene derivatives; growth metastasis; treatment ... See more keywords
PSPH promotes melanoma growth and metastasis by metabolic-deregulation–mediated transcriptional activation of NR4A1
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01683-y
Abstract: Metabolic deregulation, a hallmark of cancer, fuels cancer cell growth and metastasis. Here, we show that phosphoserine phosphatase (PSPH), an enzyme of the serine metabolism pathway, is upregulated in patient-derived melanoma samples. PSPH knockdown using… read more here.
Keywords: melanoma growth; growth; expression; psph ... See more keywords
The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis
Sign Up to like & getrecommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-022-00896-1
Abstract: PH20 is a member of the human hyaluronidase family that degrades hyaluronan in the extracellular matrix and controls tumor progression. Inhibition of DNA methyltransferases (DNMTs) leads to elevated hyaluronan levels; however, whether DNMT inhibitors control… read more here.
Keywords: pas1; breast cancer; growth metastasis; ph20 ... See more keywords
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21514-8
Abstract: N6-methyladenosine (m6A) is a reversible mRNA modification that has been shown to play important roles in various biological processes. However, the roles of m6A modification in macrophages are still unknown. Here, we discover that ablation… read more here.
Keywords: growth metastasis; macrophage; growth; rna m6a ... See more keywords
Fibulin-3 knockdown inhibits cervical cancer cell growth and metastasis in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28906-9
Abstract: To explore the function of fibulin-3 in cervical carcinoma malignant cell growth and metastasis, fibulin-3 expression in normal cervical tissue, cervical intraepithelial neoplasia (CIN), and cervical carcinoma were evaluated by immunohistochemistry. Quantitative real-time-polymerase chain reaction,… read more here.
Keywords: cervical cancer; cell growth; cancer; cervical carcinoma ... See more keywords
Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02701-1
Abstract: Hypoxia-inducible factor-1 (HIF-1) plays essential roles in human diseases, though its central role in oxygen homoeostasis hinders the development of direct HIF-1-targeted pharmacological approaches. Here, we surveyed small-molecule compounds that efficiently inhibit the transcriptional activity… read more here.
Keywords: hif; mint3; tumour growth; endotoxic shock ... See more keywords
Engineering a multi-target therapy nanoplatform against tumor growth and metastasis via a novel NSAID-Pt(IV) prodrug.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06385e
Abstract: Tumor growth and metastasis are caused by many factors. The complexity means that a multi-target combination therapy strategy should be selected against tumor growth and metastasis. Here, cisplatin (CDDP) and bendazac (Ben) were designed as… read more here.
Keywords: multi target; growth metastasis; tumor growth;