Growing Pains: The Need for Engineered Platforms to Study Growth Plate Biology
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200471
Abstract: Growth plates, or physis, are highly specialized cartilage tissues responsible for longitudinal bone growth in children and adolescents. Chondrocytes that reside in growth plates are organized into three distinct zones essential for proper function. Modeling… read more here.
Keywords: growing pains; growth; growth plate; growth plates ... See more keywords
Premature Growth Plate Closure Caused by a Hedgehog Cancer Drug Is Preventable by Co‐Administration of a Retinoid Antagonist in Mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4291
Abstract: The growth plates are key engines of skeletal development and growth and contain a top reserve zone followed by maturation zones of proliferating, prehypertrophic, and hypertrophic/mineralizing chondrocytes. Trauma or drug treatment of certain disorders can… read more here.
Keywords: closure; growth plate; drug; growth ... See more keywords
Entire calcaneus reconstruction with pedicled composite fibular growth plate flap in a pediatric patient
Sign Up to like & getrecommendations! Published in 2020 at "Microsurgery"
DOI: 10.1002/micr.30691
Abstract: Traumatic calcanectomy is a complicated rare condition that results in chronic pain and loss of limb function as the calcaneus is crucial for bearing weight. For an adult, possible treatment options are limited to below… read more here.
Keywords: reconstruction; calcaneus; flap; growth plate ... See more keywords
Magnetic resonance and diffusion tensor imaging of the adolescent rabbit growth plate of the knee
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29432
Abstract: To assess the ability of MRI‐DTI to evaluate growth plate morphology and activity compared with that of histomorphometry and micro‐CT in rabbits. read more here.
Keywords: magnetic resonance; resonance diffusion; growth plate; diffusion tensor ... See more keywords
Specific MicroRNAs Found in Extracellular Matrix Vesicles Regulate Proliferation and Differentiation in Growth Plate Chondrocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Calcified tissue international"
DOI: 10.1007/s00223-021-00855-y
Abstract: Matrix vesicles (MVs) are extracellular organelles produced by growth plate cartilage cells in a zone-specific manner. MVs are similar in size to exosomes, but they are tethered to the extracellular matrix (ECM) via integrins. Originally… read more here.
Keywords: plate chondrocytes; growth; matrix vesicles; growth plate ... See more keywords
Test yourself: right knee pain after fall
Sign Up to like & getrecommendations! Published in 2020 at "Skeletal Radiology"
DOI: 10.1007/s00256-020-03524-7
Abstract: This 12-year-old presented after hitting her right knee during a fall on a cruise ship. MRI was performed 2 weeks after the injury and demonstrated exuberant bone marrow edema throughout the proximal tibial metaphysis and… read more here.
Keywords: growth; growth plate; knee; periosteum ... See more keywords
Regulation of energy metabolism in the growth plate and osteoarthritic chondrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Rheumatology International"
DOI: 10.1007/s00296-018-4103-4
Abstract: Osteoarthritis (OA) is a chronic disorder associated mainly with pain, limited range of motion, stiffness, low-grade systemic inflammation, and articular cartilage destruction. Recent studies have demonstrated the involvement of chondrocyte differentiation (hypertrophy) as one of… read more here.
Keywords: energy metabolism; regulation energy; growth plate; energy ... See more keywords
Capacitively coupled electrical stimulation of rat chondroepiphysis explants: A histomorphometric analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Bioelectrochemistry"
DOI: 10.1016/j.bioelechem.2018.11.004
Abstract: The growth plate is a cartilaginous layer present from the gestation period until the end of puberty where it ossifies joining diaphysis and epiphysis. During this period several endocrine, autocrine, and paracrine processes within the… read more here.
Keywords: electric fields; growth plate; stimulation; chondroepiphysis ... See more keywords
Transcriptional, epigenetic and microRNA regulation of growth plate.
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115434
Abstract: Endochondral ossification is a critical event in bone formation, particularly in long shaft bones. Many cellular differentiation processes work in concert to facilitate the generation of cartilage primordium to formation of trabecular structures, all of… read more here.
Keywords: epigenetic microrna; growth plate; regulation growth; microrna regulation ... See more keywords
Enhanced BMP signalling causes growth plate cartilage dysrepair in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.115874
Abstract: Growth plate cartilage injuries often result in bony repair at the injury site and premature mineralization at the uninjured region causing bone growth defects, for which underlying mechanisms are unclear. With the prior microarray study… read more here.
Keywords: growth; growth plate; injury site; bmp signalling ... See more keywords
Radial Shockwave Treatment Promotes Chondrogenesis in Human Growth Plate and Longitudinal Bone Growth in Rabbits.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116186
Abstract: OBJECTIVE The process of longitudinal bone growth occurs at the growth plate where the chondrocytes undergo apparent structural and molecular changes to promote growth. Recent reports suggest that radial shockwave treatment (rSWT) stimulates bone length… read more here.
Keywords: growth plate; longitudinal bone; human growth; bone growth ... See more keywords