Overexpression of GRP78 enhances survival of CHO cells in response to serum deprivation and oxidative stress
Sign Up to like & getrecommendations! Published in 2017 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.201500152
Abstract: Chinese hamster ovary (CHO) cells are regarded as one of the most commonly used mammalian hosts, which decreases the productivity due to loss in culture viability. Overexpressing antiapoptosis genes in CHO cells was developed as… read more here.
Keywords: cho cells; cells response; serum deprivation; cho ... See more keywords
AAV delivery of GRP78/BiP promotes adaptation of human RPE cell to ER stress
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26296
Abstract: Adeno associated virus (AAV)‐mediated gene delivery of GRP78 (78 kDa glucose‐regulated protein) attenuates the condition of endoplasmic reticulum (ER) stress and prevents apoptotic loss of photoreceptors in Retinitis pigmentosa (RP) rats. In the current study we… read more here.
Keywords: delivery grp78; effect; stress; cell ... See more keywords
ZBM‐H‐induced activation of GRP78 ATPase promotes apoptosis via annexin A7 in A549 lung cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30224
Abstract: Hypochlorous acid (HOCl) is an essential signal for the regulation of cancer cell fate, including autophagy and apoptosis. HOCl regulated autophagy by affecting the oxidation modification of glucose‐regulated protein 78 (GRP78) and the activity of… read more here.
Keywords: grp78 atpase; zbm induced; grp78; cancer ... See more keywords
Cripto stabilizes GRP78 on the cell membrane
Sign Up to like & getrecommendations! Published in 2018 at "Protein Science"
DOI: 10.1002/pro.3358
Abstract: The ER resident chaperone molecule GRP78 has been shown to translocate to the cell surface where it associates with Cripto and signals cell growth, playing a still partially understood role in tumorigenesis. Consequently, a better… read more here.
Keywords: cripto stabilizes; stabilizes grp78; cripto; cell ... See more keywords
GRP78 inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.09.021
Abstract: New targeted therapies are urgently needed to improve the survival of patients with refractory osteosarcoma (OS). In this study, we show that bortezomib (BTZ), not for OS treatment in the clinic, induces endoplasmic reticulum (ER)… read more here.
Keywords: enhances atf4; atf4 induced; inhibition enhances; grp78 inhibition ... See more keywords
Linking cell-surface GRP78 to cancer: From basic research to clinical value of GRP78 antibodies.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.10.004
Abstract: Glucose-related protein 78 (GRP78) is a chaperone protein localized primarily in the endoplasmic reticulum (ER) lumen, where it helps in proper protein folding by targeting misfolded proteins and facilitating protein assembly. In stressed cells, GRP78… read more here.
Keywords: cancer; cell surface; clinical value; grp78 ... See more keywords
Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01631
Abstract: A recent study illustrated that a fluorescence polarization assay can be used to identify substrate-competitive Hsp70 inhibitors that can be isoform-selective. Herein, we use that assay in a moderate-throughput screen and report the discovery of… read more here.
Keywords: discovery development; development selective; grp78; chemistry ... See more keywords
CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28243-6
Abstract: Developing CAR T cells for acute myeloid leukemia (AML) has been hampered by a paucity of targets that are expressed on AML blasts and not on hematopoietic progenitor cells (HPCs). Here we demonstrate that GRP78… read more here.
Keywords: grp78; cell surface; car cells; cell ... See more keywords
Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78)
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-67746-4
Abstract: Abnormal cardiac fibrosis indicates cardiac dysfunction and poor prognosis in myocardial infarction (MI) patients. Many studies have demonstrated that the ubiquitin proteasome system (UPS) plays a significant role in the pathogenesis of fibrosis. Ubiquitin C-terminal… read more here.
Keywords: fibrosis; myocardial infarction; cardiac fibrosis; ubiquitin terminal ... See more keywords
GRP78/BiP determines senescence evasion cell fate after cisplatin-based chemotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-01540-8
Abstract: Cisplatin (CDDP) induces senescence characterized by senescence-associated secretory phenotypes (SASP) and the unfolded protein response (UPR). In this study, we investigated the proteins related to the UPR during the senescence cell fate. Strikingly, we found… read more here.
Keywords: grp78 bip; senescence; senescence evasion; cell fate ... See more keywords
The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44723
Abstract: Prion diseases are fatal neurodegenerative disorders affecting several mammalian species, characterized by the accumulation of the misfolded form of the prion protein, which is followed by the induction of endoplasmic reticulum (ER) stress and the… read more here.
Keywords: endoplasmic reticulum; vivo; prion; chaperone ... See more keywords