VEGF‐A promotes angiogenesis after acute myocardial infarction through increasing ROS production and enhancing ER stress‐mediated autophagy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28395
Abstract: Proangiogenesis is generally regarded as an effective approach for treating ischemic heart disease. Vascular endothelial growth factor (VEGF)‐A is a strong and essential proangiogenic factor. Reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, and autophagy… read more here.
Keywords: lc3; production; vegf; grp78 bip ... See more keywords
GRP78/BiP determines senescence evasion cell fate after cisplatin-based chemotherapy
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DOI: 10.1038/s41598-021-01540-8
Abstract: Cisplatin (CDDP) induces senescence characterized by senescence-associated secretory phenotypes (SASP) and the unfolded protein response (UPR). In this study, we investigated the proteins related to the UPR during the senescence cell fate. Strikingly, we found… read more here.
Keywords: grp78 bip; senescence; senescence evasion; cell fate ... See more keywords
The therapeutic mavericks: Potent immunomodulating chaperones capable of treating human diseases
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17669
Abstract: Two major chaperones, calreticulin (CRT) and binding immunoglobulin protein (GRP78/BiP) dependent on their location, have immunoregulatory or anti‐inflammatory functions respectively. CRT induces pro‐inflammatory cytokines, dendritic cell (DC) maturation and activates cytotoxic T cells against tumours.… read more here.
Keywords: crt; cell; grp78 bip; therapeutic mavericks ... See more keywords