Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00800
Abstract: As the endoplasmic reticulum paralogue of Hsp90, Grp94 chaperones a small set of client proteins associated with some diseases, including cancer, primary open-angle glaucoma, and inflammatory disorders. Grp94-selective inhibition has been a potential therapeutic strategy… read more here.
Keywords: grp94 selective; potent grp94; efficacy; mouse model ... See more keywords
Conformationally Restricted Grp94-Selective Inhibitors
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DOI: 10.1021/acsomega.4c06661
Abstract: Selective inhibition of glucose regulated protein 94 (Grp94), the most structurally unique isoform of heat shock protein 90 (Hsp90), has been implicated in the treatment of various disease states, including primary open-angle glaucoma and metastatic… read more here.
Keywords: restricted grp94; conformationally restricted; selective inhibitors; grp94 selective ... See more keywords