Distribution of the pig gastrin-releasing peptide receptor and the effect of GRP on porcine Leydig cells
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2017.09.015
Abstract: ABSTRACT Gastrin‐releasing peptide (GRP) is a mammalian bombesin (BN)‐like peptide which plays a role in a number of important physiological functions via its receptor (gastrin‐releasing peptide receptor, GRPR) in most animals. However, little is known… read more here.
Keywords: pig; grp; grpr mrna; releasing peptide ... See more keywords
Investigation of Tumor Cells and Receptor-Ligand Simulation Models for the Development of PET Imaging Probes Targeting PSMA and GRPR and a Possible Crosstalk between the Two Receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00070
Abstract: Prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) have both been used in nuclear medicine as targets for molecular imaging and therapy of prostate (PCa) and breast cancer (BCa). Three bioconjugate probes, the PSMA… read more here.
Keywords: pca; psma; receptor; grpr ... See more keywords
Design, synthesis and biological evaluation of novel 1, 3, 4-oxadiazole PD176252 analogues as potential GRPR inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520622666220501162813
Abstract: BACKGROUND GRPR is over-expressed in cancer cells and is a potential drug target for the treatment of cancer. PD176252, as the most representative non-peptide inhibitor of GRPR, can inhibit the growth of cancer cells, but… read more here.
Keywords: grpr; cancer; affinity; pd176252 ... See more keywords
Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [68Ga]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15020442
Abstract: Simple Summary Prostate cancer continues to be the most frequently diagnosed form of cancer and the leading cause of cancer-related deaths among men. For a successful treatment plan and outcome, an early diagnosis, correct staging,… read more here.
Keywords: grpr; psma grpr; prostate cancer; cancer ... See more keywords
68Ga-Labeled [Leu13ψThz14]Bombesin(7–14) Derivatives: Promising GRPR-Targeting PET Tracers with Low Pancreas Uptake
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27123777
Abstract: The gastrin-releasing peptide receptor (GRPR) is a G-protein-coupled receptor that is overexpressed in many solid cancers and is a promising target for cancer imaging and therapy. However, high pancreas uptake is a major concern in… read more here.
Keywords: grpr; pancreas uptake; thz14 bombesin; leu13 thz14 ... See more keywords
Preclinical Evaluation of 99mTc-Labeled GRPR Antagonists maSSS/SES-PEG2-RM26 for Imaging of Prostate Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13020182
Abstract: Background: Gastrin-releasing peptide receptor (GRPR) is an important target for imaging of prostate cancer. The wide availability of single-photon emission computed tomography/computed tomography (SPECT/CT) and the generator-produced 99mTc can be utilized to facilitate the use… read more here.
Keywords: prostate cancer; grpr; peg2 rm26; 99mtc masss ... See more keywords
Towards Complete Tumor Resection: Novel Dual-Modality Probes for Improved Image-Guided Surgery of GRPR-Expressing Prostate Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14010195
Abstract: Nuclear and optical dual-modality probes can be of great assistance in prostate cancer localization, providing the means for both preoperative nuclear imaging and intraoperative surgical guidance. We developed a series of probes based on the… read more here.
Keywords: grpr; dual modality; modality probes; prostate cancer ... See more keywords