Glutaredoxin 1 Deficiency Causes Late-Age Onset Metabolic Disease in Female C57BL/6 Mice, Associated with Monocyte and Macrophage Dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.318
Abstract: Glutaredoxin 1 (Grx1) reduces mixed disulfides between glutathione and protein thiols thereby controlling thiol-redox regulated cellular functions, including intracellular signaling, migration, angiogenesis, autophagy and apoptosis. Grx1 protects monocytes and macrophages from metabolic-stress-induced “priming’ and dysfunction.… read more here.
Keywords: age; grx1; dysfunction; grx1 mice ... See more keywords
The protective effect of glutaredoxin 1/DJ‐1/HSP70 signaling in renal tubular epithelial cells injury induced by ischemia
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DOI: 10.1016/j.lfs.2019.03.015
Abstract: Aims Gluaredoxin1 (GRX1) is an important protein of the cellular antioxidant defense system, but its role in renal epithelial cell injury caused by ischemia remains unclear. In this study, we aimed to gain insight into… read more here.
Keywords: injury; grx1 overexpression; grx1; hsp70 signaling ... See more keywords
Contribution of glutaredoxin-1 to Fas s-glutathionylation and inflammation in ethanol-induced liver injury.
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DOI: 10.1016/j.lfs.2020.118678
Abstract: AIMS The reversible protein S-glutathionylation (PSSG) modification of Fas augments apoptosis, which can be reversed by the cytosolic deglutathionylation enzyme glutaredoxin-1 (Grx1), but its roles in alcoholic liver injury remain unknown. Therefore, the objective of… read more here.
Keywords: fas; glutathionylation; grx1; ethanol induced ... See more keywords
Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor
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DOI: 10.1371/journal.pone.0187991
Abstract: Glutaredoxin (Grx1) is a ubiquitously expressed thiol-disulfide oxidoreductase that specifically catalyzes reduction of S-glutathionylated substrates. Grx1 is known to be a key regulator of pro-inflammatory signaling, and Grx1 silencing inhibits inflammation in inflammatory disease models.… read more here.
Keywords: anti inflammatory; j02; grx1; cwr j02 ... See more keywords