Glutaredoxin 1 Deficiency Causes Late-Age Onset Metabolic Disease in Female C57BL/6 Mice, Associated with Monocyte and Macrophage Dysfunction
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DOI: 10.1016/j.freeradbiomed.2017.10.318
Abstract: Glutaredoxin 1 (Grx1) reduces mixed disulfides between glutathione and protein thiols thereby controlling thiol-redox regulated cellular functions, including intracellular signaling, migration, angiogenesis, autophagy and apoptosis. Grx1 protects monocytes and macrophages from metabolic-stress-induced “priming’ and dysfunction.… read more here.
Keywords: age; grx1; dysfunction; grx1 mice ... See more keywords