Glioblastoma stem cells express non‐canonical proteins and exclusive mesenchymal‐like or non‐mesenchymal‐like protein signatures
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13355
Abstract: Glioblastoma’s (GBM) origin, recurrence and resistance to treatment are driven by GBM cancer stem cells (GSCs). Existing transcriptomic characterisations of GBM classify the tumours to three subtypes: classical, proneural, and mesenchymal. The comprehension of how… read more here.
Keywords: non mesenchymal; mesenchymal like; like protein; gscs ... See more keywords
RETRACTED ARTICLE: Astrocytes Regulate Differentiation and Glutamate Uptake of Glioma Stem Cells via Formyl Peptide Receptor
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00886-3
Abstract: The role of astrocytes on glutamate release and differentiation of glioma stem cells (GSCs) remains unknown. We investigated glutamate release, proliferation, and differentiation of GSCs after indirect incubation with astrocytes in vitro, including morphology change,… read more here.
Keywords: stem cells; glioma stem; glutamate uptake; differentiation ... See more keywords
The effects of type I interferon on glioblastoma cancer stem cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.098
Abstract: Glioblastomas (GBMs) are highly invasive brain tumors that are extremely deadly. The highly aggressive nature of GBM as well as its heterogeneity at the molecular and cellular levels has been attributed to a rare subpopulation… read more here.
Keywords: cancer stem; effects type; gscs; stem ... See more keywords
Identification of two mitochondrial-targeting cyclometalated iridium(III) complexes as potent anti-glioma stem cells agents.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2019.110909
Abstract: Glioma stem cells (GSCs) are thought to be responsible for the recurrence and invasion of glioblastoma multiform (GBM), which have been evaluated and exploited as the therapeutic target for GBM. Cyclometalated iridium(III) complexes have been… read more here.
Keywords: gscs; iii complexes; iridium iii; cyclometalated iridium ... See more keywords
MCM8 is regulated by EGFR signaling and promotes the growth of glioma stem cells through its interaction with DNA-replication-initiating factors
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01888-1
Abstract: Mini-chromosome maintenance (MCM) proteins are critical components of DNA-replication-licensing factors. MCM8 is an MCM protein that exhibits oncogenic functions in several human malignancies. However, the role of MCM8 in glioblastomas (GBMs) has remained unclear. In… read more here.
Keywords: mcm8; regulated egfr; dna replication; expression ... See more keywords
Oct4A palmitoylation modulates tumorigenicity and stemness in human glioblastoma cells.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac157
Abstract: BACKGROUND Glioblastoma multiforme and other solid malignancies are heterogeneous, containing subpopulations of tumor cells that exhibit stem characteristics. Oct4, also known as POU5F1, is a key transcription factor in the self-renewal, proliferation, and differentiation of… read more here.
Keywords: glioblastoma; tumorigenicity; oct4a palmitoylation; gscs ... See more keywords
Abstract 3869: Cell surface vimentin targeted mAb 86C increases sensitivity to temozolomide mediated cell death in glioma stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-3869
Abstract: Glioblastoma multiforme (GBM) is one of the most aggressive brain tumor in pediatric patients. The current standard of care including radiation and chemotherapy is not effective in most patients due to multiple factors such as… read more here.
Keywords: stem cells; glioma stem; csv; surface ... See more keywords
The heterogeneous cellular states of glioblastoma stem cells revealed by single cell analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.2139/ssrn.4012590
Abstract: Glioblastoma stem cells (GSCs) contributed to the progression, treatment resistance and relapse of glioblastoma (GBM). However, current researches on GSCs were performed usually outside the human tumor microenvironment, ignoring the importance of the cellular states… read more here.
Keywords: cell; glioblastoma stem; gscs; tumor ... See more keywords
Adapt to Persist: Glioblastoma Microenvironment and Epigenetic Regulation on Cell Plasticity
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11020313
Abstract: Simple Summary Glioblastoma stem-like cells (GSCs) drive the progression and therapeutic resistance of glioblastoma. GSC plasticity allows them to adapt to different microenvironments and to persist after treatments. GSCs can reside in hypoxic, invasive and… read more here.
Keywords: cell; glioblastoma; microenvironment; plasticity ... See more keywords
Glioblastoma Embryonic-like Stem Cells Exhibit Immune-Evasive Phenotype.
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14092070
Abstract: BACKGROUND Glioma stem cells (GSCs) have self-renewal and tumor-initiating capacities involved in drug resistance and immune evasion mechanisms in glioblastoma (GBM). METHODS Core-GSCs (c-GSCs) were identified by selecting cells co-expressing high levels of embryonic stem… read more here.
Keywords: glioblastoma; phenotype; immune evasive; gscs ... See more keywords
Glioma Stem Cells in Pediatric High-Grade Gliomas: From Current Knowledge to Future Perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14092296
Abstract: Simple Summary Pediatric high-grade glioma (pHGG) has a dismal prognosis in which the younger the patient, the more restricted the treatments are, in regard to the incurred risks. Current therapies destroy many tumor cells but… read more here.
Keywords: glioma stem; high grade; stem cells; gscs ... See more keywords