GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjy056
Abstract: Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce… read more here.
Keywords: gsdmb promotes; gsdmb; caspase activity; canonical pyroptosis ... See more keywords
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.aaz7548
Abstract: Granzyme A lights a fire Cytotoxic T cells and natural killer cells use several strategies to kill infected or transformed cells. One such pathway entails the delivery of a family of serine proteases called granzymes… read more here.
Keywords: gsdmb; pyroptosis; cytotoxic; expression ... See more keywords
Upregulated GSDMB in Clear Cell Renal Cell Carcinoma Is Associated with Immune Infiltrates and Poor Prognosis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Immunology Research"
DOI: 10.1155/2021/7753553
Abstract: Gasdermin B (GSDMB) is part of the gasdermin (GSDM) family, and they use varying means of domain interactions in molecules to adjust their pore-forming and lipid-binding actions. The GSDM family has roles in the regulation… read more here.
Keywords: analysis; expression; cell; ccrcc ... See more keywords
The study of GSDMB in pathogenesis of psoriasis vulgaris
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0279908
Abstract: Background Gasdermin (GSDM) B is a member of the GSDM family, which is a protein that may be involved in the cell pyroptosis process and is associated with inflammatory diseases. Objective To explore the correlation… read more here.
Keywords: psoriasis vulgaris; cell; gsdmb; pathogenesis psoriasis ... See more keywords
Anlotinib Enhances the Therapeutic Effect of Bladder Cancer with GSDMB Expression: Analyzed from TCGA Bladder Cancer Database & Mouse Bladder Cancer Cell Line
Sign Up to like & getrecommendations! Published in 2023 at "Pharmacogenomics and Personalized Medicine"
DOI: 10.2147/pgpm.s398451
Abstract: Introduction and Objective The mitogen-activated protein kinase (MAPK) pathway is inhibited by the pan-target inhibitor Anlotinib, which induces tumor cell death. In addition to the common apoptosis and necrosis, there is also a pyroptosis mode… read more here.
Keywords: bladder; anlotinib; expression; gsdmb ... See more keywords