P059 GSDMB triggers intestinal inflammation via regulating BHLHA15-mediated hyperactive unfolded protein response
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjad212.0189
Abstract: Impaired intestinal epithelial barrier has been considered to be associated with an increasing variety of gastrointestinal diseases, especially inflammatory bowel disease (IBD) encompassing Crohn’s disease (CD) and ulcerative colitis (UC). Herein, we investigated the role… read more here.
Keywords: intestinal epithelial; barrier; villin cre; gsdmb ... See more keywords
GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjy056
Abstract: Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce… read more here.
Keywords: gsdmb promotes; gsdmb; caspase activity; canonical pyroptosis ... See more keywords
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.aaz7548
Abstract: Granzyme A lights a fire Cytotoxic T cells and natural killer cells use several strategies to kill infected or transformed cells. One such pathway entails the delivery of a family of serine proteases called granzymes… read more here.
Keywords: gsdmb; pyroptosis; cytotoxic; expression ... See more keywords
Upregulated GSDMB in Clear Cell Renal Cell Carcinoma Is Associated with Immune Infiltrates and Poor Prognosis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Immunology Research"
DOI: 10.1155/2021/7753553
Abstract: Gasdermin B (GSDMB) is part of the gasdermin (GSDM) family, and they use varying means of domain interactions in molecules to adjust their pore-forming and lipid-binding actions. The GSDM family has roles in the regulation… read more here.
Keywords: analysis; expression; cell; ccrcc ... See more keywords
[email protected] nanoparticle for regulates the expression of GSDMB and targeted therapy of tumor
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Cell International"
DOI: 10.1186/s12935-025-03874-z
Abstract: GSDMB, a key protein in pyroptosis, is closely linked to various diseases. Nanomaterials can target and regulate specific pathways. Herein, we report a simple and efficient one-step method to develop multi-enzyme nanoparticles capable of suppressing… read more here.
Keywords: cu5 nanoparticle; 5zno cu5; tumor; gsdmb ... See more keywords
The study of GSDMB in pathogenesis of psoriasis vulgaris
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0279908
Abstract: Background Gasdermin (GSDM) B is a member of the GSDM family, which is a protein that may be involved in the cell pyroptosis process and is associated with inflammatory diseases. Objective To explore the correlation… read more here.
Keywords: psoriasis vulgaris; cell; gsdmb; pathogenesis psoriasis ... See more keywords
Anlotinib Enhances the Therapeutic Effect of Bladder Cancer with GSDMB Expression: Analyzed from TCGA Bladder Cancer Database & Mouse Bladder Cancer Cell Line
Sign Up to like & getrecommendations! Published in 2023 at "Pharmacogenomics and Personalized Medicine"
DOI: 10.2147/pgpm.s398451
Abstract: Introduction and Objective The mitogen-activated protein kinase (MAPK) pathway is inhibited by the pan-target inhibitor Anlotinib, which induces tumor cell death. In addition to the common apoptosis and necrosis, there is also a pyroptosis mode… read more here.
Keywords: bladder; anlotinib; expression; gsdmb ... See more keywords