Hepatocyte‐Specific GSDMD Deficiency Aggravates Sepsis by Disrupting Non‐Canonical Secretion of Anti‐Inflammatory Factors
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DOI: 10.1002/advs.202510412
Abstract: Gasdermin D (GSDMD)‐mediated pyroptosis in macrophages plays a clear role in promoting inflammation and mortality in sepsis. The liver is a commonly damaged organ during sepsis and also an important organ for releasing acute response… read more here.
Keywords: specific gsdmd; gsdmd; inflammatory factors; hepatocyte specific ... See more keywords
Aloe vera gel confers therapeutic effect by reducing pyroptosis in ethanol-induced gastric ulcer rat model: Role of NLRP3/GSDMD signaling pathway
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DOI: 10.1007/s11033-024-09329-4
Abstract: Gastric ulcer (GU) is a common gastrointestinal tract illness. Aloe vera has anti-inflammatory, antioxidant, and healing characteristics. This research sought to explore the therapeutic impact of Aloe vera gel on ethanol-provoked GU in rats and… read more here.
Keywords: aloe vera; gsdmd; vera; group ... See more keywords
Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway
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DOI: 10.1007/s12035-020-02144-5
Abstract: Nod-like receptor protein 3 (NLRP3)-associated neuroinflammation mediated by activated microglia is involved in the pathogenesis of depression. The role of the pore-forming protein gasdermin D (GSDMD), a newly identified pyroptosis executioner downstream of NLRP3 inflammasome… read more here.
Keywords: depression; casp; paeoniflorin; pyroptosis ... See more keywords
Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.07.027
Abstract: IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-dependent GSDMD cleavage, which also induces pyroptosis. Mechanisms of IL-1β secretion by pyroptotic and non-pyroptotic cells, and the… read more here.
Keywords: secretion; gsdmd; independent secretion; maturation ... See more keywords
Ion Man: GSDMD Punches Pores to Knock Out cGAS.
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.08.026
Abstract: The pore-forming protein GSDMD promotes cytokine release and induces pyroptotic cell death. In this issue of Immunity, Banerjee et al. (2018) document how GSDMD triggers potassium efflux to inhibit cGAS-STING and prevent damaging interferon production after… read more here.
Keywords: punches pores; ion man; man gsdmd; pores knock ... See more keywords
FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.04.002
Abstract: Pathways controlling intestinal epithelial cell (IEC) death regulate gut immune homeostasis and contribute to the pathogenesis of inflammatory bowel diseases. Here, we show that caspase-8 and its adapter FADD act in IECs to regulate intestinal… read more here.
Keywords: caspase; death; intestinal epithelial; mlkl ... See more keywords
Xanthoangelol modulates Caspase-1-dependent pyroptotic death among hepatocellular carcinoma cells with high expression of GSDMD
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2021.104577
Abstract: Abstract Xanthoangelol (XAG), a major chalcone presents in Angelica keiskei, has been employed in research to develop functional supplements or drugs due to its various pharmacological activities. Here, we investigated the underlying mechanism of XAG-induced… read more here.
Keywords: hepatocellular carcinoma; pyroptotic death; expression gsdmd; death ... See more keywords
From the Editor's desk....: April 2018.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2018.01.013
Abstract: Xu et al., 2018. Hepatic pyroptosis in NASH Hepatic pyroptosis in NASH There is a clear need to identify molecular mechanisms of nonalcoholic steatohepatitis (NASH) to develop novel targeted therapies. Pyroptosis is a highly inflammatory… read more here.
Keywords: april 2018; pyroptosis; nash; editor desk ... See more keywords
CCL11 released by GSDMD-mediated macrophage pyroptosis regulates angiogenesis after hindlimb ischemia
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DOI: 10.1038/s41420-023-01764-9
Abstract: Peripheral vascular disease (PVD) is an emerging public health burden with a high rate of disability and mortality. Gasdermin D (GSDMD) has been reported to exert pyroptosis and play a critical role in the pathophysiology… read more here.
Keywords: gsdmd mediated; hindlimb ischemia; pyroptosis; gsdmd ... See more keywords
Metformin modulates the TXNIP-NLRP3-GSDMD pathway to improve diabetic bladder dysfunction
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DOI: 10.1038/s41598-024-72129-0
Abstract: To validate the therapeutic efficacy of metformin on diabetic bladder dysfunction (DBD) and further elucidate whether the TXNIP-NLRP3-GSDMD axis serves as a target for metformin in ameliorating DBD. C57BL/6J mice were induced with diet-induced obesity… read more here.
Keywords: mice; txnip nlrp3; gsdmd; bladder ... See more keywords
Butin regulates the NLRP3/CASP-1/GSDMD pyroptosis axis to inhibit proliferation and pyroptosis in human fibroblast-like synoviocytes of rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-17239-z
Abstract: To investigate the mechanism by which Butin inhibits proliferation and pyroptosis in human fibroblast-like synoviocytes of rheumatoid arthritis (HFLS-RA) via the NLRP3/Caspase-1/ GSDMD pyroptosis axis. Flavonoid compounds were extracted from Hei Gu Teng, and Butin… read more here.
Keywords: proliferation pyroptosis; pyroptosis; pharmacology; gsdmd ... See more keywords