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   Articles with "gsdmd" as a keyword



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Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway

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recommendations! Published in 2020 at "Molecular Neurobiology"

DOI: 10.1007/s12035-020-02144-5

Abstract: Nod-like receptor protein 3 (NLRP3)-associated neuroinflammation mediated by activated microglia is involved in the pathogenesis of depression. The role of the pore-forming protein gasdermin D (GSDMD), a newly identified pyroptosis executioner downstream of NLRP3 inflammasome… read more here.

Keywords: depression; casp; paeoniflorin; pyroptosis ... See more keywords
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Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion.

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.07.027

Abstract: IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-dependent GSDMD cleavage, which also induces pyroptosis. Mechanisms of IL-1β secretion by pyroptotic and non-pyroptotic cells, and the… read more here.

Keywords: secretion; gsdmd; independent secretion; maturation ... See more keywords
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Ion Man: GSDMD Punches Pores to Knock Out cGAS.

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recommendations! Published in 2018 at "Immunity"

DOI: 10.1016/j.immuni.2018.08.026

Abstract: The pore-forming protein GSDMD promotes cytokine release and induces pyroptotic cell death. In this issue of Immunity, Banerjee et al. (2018) document how GSDMD triggers potassium efflux to inhibit cGAS-STING and prevent damaging interferon production after… read more here.

Keywords: punches pores; ion man; man gsdmd; pores knock ... See more keywords
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FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.

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recommendations! Published in 2020 at "Immunity"

DOI: 10.1016/j.immuni.2020.04.002

Abstract: Pathways controlling intestinal epithelial cell (IEC) death regulate gut immune homeostasis and contribute to the pathogenesis of inflammatory bowel diseases. Here, we show that caspase-8 and its adapter FADD act in IECs to regulate intestinal… read more here.

Keywords: caspase; death; intestinal epithelial; mlkl ... See more keywords
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Xanthoangelol modulates Caspase-1-dependent pyroptotic death among hepatocellular carcinoma cells with high expression of GSDMD

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recommendations! Published in 2021 at "Journal of Functional Foods"

DOI: 10.1016/j.jff.2021.104577

Abstract: Abstract Xanthoangelol (XAG), a major chalcone presents in Angelica keiskei, has been employed in research to develop functional supplements or drugs due to its various pharmacological activities. Here, we investigated the underlying mechanism of XAG-induced… read more here.

Keywords: hepatocellular carcinoma; pyroptotic death; expression gsdmd; death ... See more keywords
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From the Editor's desk....: April 2018.

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recommendations! Published in 2018 at "Journal of hepatology"

DOI: 10.1016/j.jhep.2018.01.013

Abstract: Xu et al., 2018. Hepatic pyroptosis in NASH Hepatic pyroptosis in NASH There is a clear need to identify molecular mechanisms of nonalcoholic steatohepatitis (NASH) to develop novel targeted therapies. Pyroptosis is a highly inflammatory… read more here.

Keywords: april 2018; pyroptosis; nash; editor desk ... See more keywords
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Maternal Serum Gasdermin D Concentrations in Pregnancies Complicated by Isolated Intrauterine Growth Restriction.

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recommendations! Published in 2022 at "Zeitschrift fur Geburtshilfe und Neonatologie"

DOI: 10.1055/a-1967-2274

Abstract: Abstract Objective We aimed to investigate the relationship between the isolated intrauterine growth restriction (IUGR) and maternal serum gasdermin D (GSDMD) concentration. Materials and methods This cross-sectional study was conducted with 80 pregnant women who… read more here.

Keywords: gsdmd; group; maternal serum; iugr group ... See more keywords
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GSDMD-mediated pyroptosis promotes cardiac remodeling in pressure overload.

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recommendations! Published in 2023 at "Clinical and experimental hypertension"

DOI: 10.1080/10641963.2023.2189138

Abstract: BACKGROUND Gasdermin D (GSDMD) forms membrane pores to execute pyroptosis. But the mechanism of how cardiomyocyte pyroptosis induces cardiac remodeling in pressure overload remains unclear. We investigated the role of GSDMD-mediated pyroptosis in the pathogenesis… read more here.

Keywords: gsdmd; pressure overload; pyroptosis; cardiac remodeling ... See more keywords
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Talaromyces marneffei activates the AIM2-caspase-1/-4-GSDMD axis to induce pyroptosis in hepatocytes

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recommendations! Published in 2022 at "Virulence"

DOI: 10.1080/21505594.2022.2080904

Abstract: ABSTRACT Talaromyces marneffei tends to induce systemic infection in immunocompromised individuals, which is one of the causes of the high mortality. The underlying molecular mechanisms of T.marneffei-induced abnormal liver function are still poorly understood. In… read more here.

Keywords: gsdmd; pyroptosis; aim2 caspase; talaromyces marneffei ... See more keywords

Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast

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recommendations! Published in 2022 at "Open Biology"

DOI: 10.1098/rsob.220366

Abstract: Gasdermin D (GSDMD) and mixed lineage kinase domain-like protein (MLKL) are the pore-forming effectors of pyroptosis and necroptosis, respectively, with the capacity to disturb plasma membrane selective permeability and induce programmed cell death. The budding… read more here.

Keywords: gasdermin; gsdmd; torc1; mlkl ... See more keywords
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Caspase‐7 mediates caspase‐1‐induced apoptosis independently of Bid

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recommendations! Published in 2019 at "Microbiology and Immunology"

DOI: 10.1111/1348-0421.12756

Abstract: Inflammasomes are innate immune mechanisms that activate caspase‐1 in response to a variety of stimuli, including Salmonella infection. Active caspase‐1 has a potential to induce two different types of cell death, depending on the expression… read more here.

Keywords: caspase; caspase activation; apoptosis; caspase induced ... See more keywords