Circadian disruption by simulated shift work aggravates periodontitis via orchestrating BMAL1 and GSDMD-mediated pyroptosis
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Oral Science"
DOI: 10.1038/s41368-024-00331-x
Abstract: Approximately 20% to 30% of the global workforce is engaged in shift work. As a significant cause of circadian disruption, shift work is closely associated with an increased risk for periodontitis. Nevertheless, how shift work-related… read more here.
Keywords: gsdmd mediated; shift work; circadian disruption; work ... See more keywords
CCL11 released by GSDMD-mediated macrophage pyroptosis regulates angiogenesis after hindlimb ischemia
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death Discovery"
DOI: 10.1038/s41420-023-01764-9
Abstract: Peripheral vascular disease (PVD) is an emerging public health burden with a high rate of disability and mortality. Gasdermin D (GSDMD) has been reported to exert pyroptosis and play a critical role in the pathophysiology… read more here.
Keywords: gsdmd mediated; hindlimb ischemia; pyroptosis; gsdmd ... See more keywords
NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression
Sign Up to like & getrecommendations! Published in 2021 at "JCI Insight"
DOI: 10.1172/jci.insight.146852
Abstract: Emerging evidence suggests that astrocyte loss is one of the most important pathological features in the hippocampus of patients with major depressive disorder (MDD) and depressive mice. Pyroptosis is a recently discovered form of programmed… read more here.
Keywords: gsdmd mediated; gsdmd; pyroptosis; pathological injury ... See more keywords