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   Articles with "gsdme" as a keyword



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Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis

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recommendations! Published in 2021 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-021-04078-0

Abstract: Secondary necrosis has long been perceived as an uncontrolled process resulting in total lysis of the apoptotic cell. Recently, it was shown that progression of apoptosis to secondary necrosis is regulated by Gasdermin E (GSDME),… read more here.

Keywords: necrosis; apoptosis; plasma membrane; secondary necrosis ... See more keywords
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The deafness gene GSDME: its involvement in cell apoptosis, secondary necrosis, and cancers

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recommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"

DOI: 10.1007/s00210-019-01674-7

Abstract: Gasdermin E (GSDME), also called DFNA5, is a member of the gasdermin family. GSDME is involved in the regulation of apoptosis and necrosis. The N-terminal domain of GSDME displays an apoptosis-inducing activity while the C-terminal… read more here.

Keywords: necrosis; deafness gene; apoptosis; gsdme ... See more keywords
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Oncostatin M sensitizes keratinocytes to UVB-induced inflammation via GSDME-mediated pyroptosis.

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recommendations! Published in 2021 at "Journal of dermatological science"

DOI: 10.1016/j.jdermsci.2021.09.004

Abstract: BACKGROUND Oncostatin M (OSM), an interleukin-6 (IL-6) family proinflammatory cytokine, plays a critical role in inflammatory skin diseases, but its mechanism of action is not well understood. OBJECTIVE To demonstrate the mechanism of OSM induced… read more here.

Keywords: induced inflammation; gsdme; hacat cells; uvb induced ... See more keywords
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Gasdermin: a novel therapeutic target for tumour treatment by activating anti-tumour immunity

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recommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-020-0180-4

Abstract: A very recent study by Zhang et al. published in Nature demonstrates that gasdermin E (GSDME, also known as DFNA5) is a tumour suppressor by activating caspaseindependent pyroptosis to enhance anti-tumour immunity. In the meantime,… read more here.

Keywords: immunity; pyroptosis; gsdme; tumour suppression ... See more keywords
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GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy.

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recommendations! Published in 2021 at "Cell death and differentiation"

DOI: 10.1038/s41418-021-00755-6

Abstract: Renal tubular cell (RTC) death and inflammation contribute to the progression of obstructive nephropathy, but its underlying mechanisms have not been fully elucidated. Here, we showed that Gasdermin E (GSDME) expression level and GSDME-N domain… read more here.

Keywords: inflammation fibrosis; gsdme mediated; obstructive nephropathy; gsdme ... See more keywords
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Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

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recommendations! Published in 2022 at "Neuron"

DOI: 10.1101/2022.11.01.513927

Abstract: Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin (GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their roles in the central nervous system (CNS) are not well understood. Here,… read more here.

Keywords: loss; gsdme; neurite loss; motor ... See more keywords

Osthole Induces Apoptosis and Caspase-3/GSDME-Dependent Pyroptosis via NQO1-Mediated ROS Generation in HeLa Cells

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/8585598

Abstract: Osthole is a natural coumarin which has been proved to inhibit growth of cancer cells by inducing cell death, while its mechanism was considered to be just caused by apoptosis. In our study, we found… read more here.

Keywords: apoptosis; pyroptosis; gsdme; caspase ... See more keywords
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Cyclophosphamide induced intestinal injury is alleviated by blocking the TLR9/caspase3/GSDME mediated intestinal epithelium pyroptosis.

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recommendations! Published in 2023 at "International immunopharmacology"

DOI: 10.2139/ssrn.4255218

Abstract: OBJECTIVES Cyclophosphamide (CYC) was commonly used to treat autoimmune disorders, and it could also cause side effects such as intestinal damage. This study aimed to explore the mechanism of CYC-induced intestinal cytotoxicity and provide evidence… read more here.

Keywords: induced intestinal; tlr9 caspase3; pyroptosis; gsdme ... See more keywords

Lobaplatin induces pyroptosis in cervical cancer cells via caspase-3/GSDME pathway.

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recommendations! Published in 2021 at "Anti-cancer agents in medicinal chemistry"

DOI: 10.2174/1871520621666211018100532

Abstract: BACKGROUND Increasing evidence shows that GSDME is involved in tumor chemotherapy. Lobaplatin is an important chemotherapy drug for the treatment of cervical cancer. However, the exact mechanism of lobaplatin in the treatment of cervical cancer… read more here.

Keywords: caspase; pyroptosis; gsdme; cervical cancer ... See more keywords
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Prognostic and Immunological Role of Gasdermin E in Pan-Cancer Analysis

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recommendations! Published in 2021 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2021.706266

Abstract: Despite accumulating cell- or animal-based experiments providing the relationship between Gasdermin E (GSDME) and human diseases, especially in malignant cancers, no pan-cancer analysis about the function of GSMDE in cancer management can be available up… read more here.

Keywords: pan cancer; analysis; gsdme; cancer analysis ... See more keywords

Knocking down GALNT6 promotes pyroptosis of pancreatic ductal adenocarcinoma cells through NF-κB/NLRP3/GSDMD and GSDME signaling pathway

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recommendations! Published in 2023 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2023.1097772

Abstract: Background Pancreatic ductal adenocarcinoma (PDAC), the most prevalent type of pancreatic cancer, is a highly lethal malignancy with poor prognosis. Polypeptide N-acetylgalactosaminyltransferase-6 (GALNT6) is frequently overexpressed in PDAC. However, the role of GALNT6 in the… read more here.

Keywords: galnt6; nlrp3 gsdmd; gsdme; expression ... See more keywords