Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-04078-0
Abstract: Secondary necrosis has long been perceived as an uncontrolled process resulting in total lysis of the apoptotic cell. Recently, it was shown that progression of apoptosis to secondary necrosis is regulated by Gasdermin E (GSDME),… read more here.
Keywords: necrosis; apoptosis; plasma membrane; secondary necrosis ... See more keywords
The deafness gene GSDME: its involvement in cell apoptosis, secondary necrosis, and cancers
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01674-7
Abstract: Gasdermin E (GSDME), also called DFNA5, is a member of the gasdermin family. GSDME is involved in the regulation of apoptosis and necrosis. The N-terminal domain of GSDME displays an apoptosis-inducing activity while the C-terminal… read more here.
Keywords: necrosis; deafness gene; apoptosis; gsdme ... See more keywords
Oncostatin M sensitizes keratinocytes to UVB-induced inflammation via GSDME-mediated pyroptosis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2021.09.004
Abstract: BACKGROUND Oncostatin M (OSM), an interleukin-6 (IL-6) family proinflammatory cytokine, plays a critical role in inflammatory skin diseases, but its mechanism of action is not well understood. OBJECTIVE To demonstrate the mechanism of OSM induced… read more here.
Keywords: induced inflammation; gsdme; hacat cells; uvb induced ... See more keywords
Gasdermin: a novel therapeutic target for tumour treatment by activating anti-tumour immunity
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-0180-4
Abstract: A very recent study by Zhang et al. published in Nature demonstrates that gasdermin E (GSDME, also known as DFNA5) is a tumour suppressor by activating caspaseindependent pyroptosis to enhance anti-tumour immunity. In the meantime,… read more here.
Keywords: immunity; pyroptosis; gsdme; tumour suppression ... See more keywords
GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00755-6
Abstract: Renal tubular cell (RTC) death and inflammation contribute to the progression of obstructive nephropathy, but its underlying mechanisms have not been fully elucidated. Here, we showed that Gasdermin E (GSDME) expression level and GSDME-N domain… read more here.
Keywords: inflammation fibrosis; gsdme mediated; obstructive nephropathy; gsdme ... See more keywords
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "Neuron"
DOI: 10.1101/2022.11.01.513927
Abstract: Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin (GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their roles in the central nervous system (CNS) are not well understood. Here,… read more here.
Keywords: loss; gsdme; neurite loss; motor ... See more keywords
Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Gut"
DOI: 10.1136/gutjnl-2024-332281
Abstract: Background Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for therapeutic development remain less understood. Objective We aimed to identify ICB resistance-associated… read more here.
Keywords: hepatocellular carcinoma; icb; stat1 gsdme; gsdme ... See more keywords
Osthole Induces Apoptosis and Caspase-3/GSDME-Dependent Pyroptosis via NQO1-Mediated ROS Generation in HeLa Cells
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/8585598
Abstract: Osthole is a natural coumarin which has been proved to inhibit growth of cancer cells by inducing cell death, while its mechanism was considered to be just caused by apoptosis. In our study, we found… read more here.
Keywords: apoptosis; pyroptosis; gsdme; caspase ... See more keywords
GSDME-N-induced mitochondrial neurotoxicity in early neurodegeneration was suppressed by nicotine via enhancing autophagic flux
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-07247-y
Abstract: Neurodegeneration is a chronic, progressive process initiated by early neurite retraction, a pathological hallmark preceding neuronal death in neurodegenerative disorders such as Parkinson’s disease (PD). Cleavage of gasdermin E (GSDME) releases its N-terminal domain (GSDME-N),… read more here.
Keywords: neurite retraction; early neurodegeneration; gsdme; neurodegeneration ... See more keywords
Cyclophosphamide induced intestinal injury is alleviated by blocking the TLR9/caspase3/GSDME mediated intestinal epithelium pyroptosis.
Sign Up to like & getrecommendations! Published in 2023 at "International immunopharmacology"
DOI: 10.2139/ssrn.4255218
Abstract: OBJECTIVES Cyclophosphamide (CYC) was commonly used to treat autoimmune disorders, and it could also cause side effects such as intestinal damage. This study aimed to explore the mechanism of CYC-induced intestinal cytotoxicity and provide evidence… read more here.
Keywords: induced intestinal; tlr9 caspase3; pyroptosis; gsdme ... See more keywords
Lobaplatin induces pyroptosis in cervical cancer cells via caspase-3/GSDME pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520621666211018100532
Abstract: BACKGROUND Increasing evidence shows that GSDME is involved in tumor chemotherapy. Lobaplatin is an important chemotherapy drug for the treatment of cervical cancer. However, the exact mechanism of lobaplatin in the treatment of cervical cancer… read more here.
Keywords: caspase; pyroptosis; gsdme; cervical cancer ... See more keywords