Amorphous Ultra‐Small Fe‐Based Nanocluster Engineered and ICG Loaded Organo‐Mesoporous Silica for GSH Depletion and Photothermal‐Chemodynamic Synergistic Therapy
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DOI: 10.1002/adhm.202201986
Abstract: Intracellular oxidative amplification can effectively destroy tumor cells. Additionally, Fe‐mediated Fenton reaction often converts cytoplasm H2O2 to generate extensive hypertoxic hydroxyl radical (•OH), leading to irreversible mitochondrion damage for tumor celleradication, which is widely famous… read more here.
Keywords: gsh; organo mesoporous; loaded organo; icg loaded ... See more keywords
Visualizing GSH‐ONOO− Redox and Tracking Lesion‐Remedy of Acute Kidney Oxidative Injury Based on a Dual‐Site Chemosensor
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DOI: 10.1002/adhm.202500907
Abstract: Drug‐induced acute kidney injury (DIAKI) is strongly associated with the accumulation of peroxynitrite (ONOO−) and the depletion of glutathione (GSH), both of which contribute to increased morbidity and mortality. Owing to the lack of an… read more here.
Keywords: gsh onoo; dual site; gsh; onoo redox ... See more keywords
GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility
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DOI: 10.1002/advs.202519368
Abstract: This study identifies glutathione (GSH) as an endogenous A‐A type allosteric activator of pyruvate kinase M2 (PKM2), stabilizing it in its active tetrameric form through binding at the A‐A interface. This PKM2‐GSH interaction links GSH… read more here.
Keywords: type allosteric; pkm2; allosteric activator; ferroptosis ... See more keywords
Synthesis of Glutathione (GSH)-Responsive Amphiphilic Duplexes and their Application in Gene Delivery.
Sign Up to like & getrecommendations! Published in 2019 at "ChemPlusChem"
DOI: 10.1002/cplu.201900295
Abstract: Oligoamide molecular strands with hydrogen-bonding sequences DADDAD and guanidine (O-1) or 1,5,9-triazacyclododecane ([12]aneN3 ; O-2) side chains and oligoamides with hydrogen-bonding sequences ADAADA and octyl moieties (O-3), were synthesized. Two duplexes (D-1 and D-2) were… read more here.
Keywords: synthesis glutathione; glutathione gsh; gsh responsive; responsive amphiphilic ... See more keywords
In‐vivo two‐photon visualization and quantitative detection of redox state of cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biophotonics"
DOI: 10.1002/jbio.202100357
Abstract: Glutathione (GSH), the most common and abundant antioxidant in the body, is particularly concentrated in cancer cells (2–10 mM). This concentration is approximately 1000 times that of normal cells, making GSH a specific tumor marker. Overexpression… read more here.
Keywords: gsh; two photon; redox; tpef gsh ... See more keywords
Hydrogen treatment reduces tendon adhesion and inflammatory response
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DOI: 10.1002/jcb.27441
Abstract: A rat model of tendon repair was established to investigate the effects of hydrogen water on tendon adhesion reduction. Thirty‐six Sprague Dawley rats were randomly divided into a normal saline (NS) group and a hydrogen… read more here.
Keywords: sod; hydrogen; group; gsh ... See more keywords
Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES‐1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor
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DOI: 10.1002/minf.202200140
Abstract: A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active… read more here.
Keywords: dynamics simulations; gsh; role; molecular dynamics ... See more keywords
Hadamard editing of glutathione and macromolecule‐suppressed GABA
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DOI: 10.1002/nbm.3844
Abstract: The primary inhibitory neurotransmitter γ‐aminobutyric acid (GABA) and the major antioxidant glutathione (GSH) are compounds of high importance for the function and integrity of the human brain. In this study, a method for simultaneous J‐difference… read more here.
Keywords: suppressed hermes; mega press; gsh; gaba ... See more keywords
Is GSH Chelated Pt Molecule Inactive in Anti-Cancer Treatment? A Case Study of Pt6 GS4.
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DOI: 10.1002/smll.202002044
Abstract: Platinum (Pt) drugs are widely used in anti-cancer treatment although many reports advocated that tumor cells could inactivate Pt drugs via glutathione-Pt (GSH-Pt) adducts formation. To date, GSH chelated Pt molecules have not been assessed… read more here.
Keywords: cancer; cancer treatment; pt6 gs4; gsh ... See more keywords
Fe(III)-Naphthazarin Metal-Phenolic Networks for Glutathione-Depleting Enhanced Ferroptosis-Apoptosis Combined Cancer Therapy.
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DOI: 10.1002/smll.202207825
Abstract: Nowadays, Fenton chemistry-based chemodynamic therapy (CDT) is an emerging approach to killing tumor cells by converting endogenous H2 O2 into cytotoxic hydroxyl radicals (·OH). However, the elimination of ·OH by intracellular overexpressed glutathione (GSH) results… read more here.
Keywords: gsh; metal phenolic; therapy; phenolic networks ... See more keywords
Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02793-4
Abstract: Paracetamol (acetaminophen, APAP) overdose is a leading cause of acute drug-induced liver failure. APAP hepatotoxicity is mediated by the reactive metabolite N-acetyl- p -benzoquinone imine (NAPQI). NAPQI is inactivated by conjugation with glutathione (GSH) to… read more here.
Keywords: apap cys; cellular efflux; apap; gsh ... See more keywords