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Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201986
Abstract: Intracellular oxidative amplification can effectively destroy tumor cells. Additionally, Fe‐mediated Fenton reaction often converts cytoplasm H2O2 to generate extensive hypertoxic hydroxyl radical (•OH), leading to irreversible mitochondrion damage for tumor celleradication, which is widely famous…
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Keywords:
gsh;
organo mesoporous;
loaded organo;
icg loaded ... See more keywords
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Published in 2019 at "ChemPlusChem"
DOI: 10.1002/cplu.201900295
Abstract: Oligoamide molecular strands with hydrogen-bonding sequences DADDAD and guanidine (O-1) or 1,5,9-triazacyclododecane ([12]aneN3 ; O-2) side chains and oligoamides with hydrogen-bonding sequences ADAADA and octyl moieties (O-3), were synthesized. Two duplexes (D-1 and D-2) were…
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Keywords:
synthesis glutathione;
glutathione gsh;
gsh responsive;
responsive amphiphilic ... See more keywords
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Published in 2022 at "Journal of Biophotonics"
DOI: 10.1002/jbio.202100357
Abstract: Glutathione (GSH), the most common and abundant antioxidant in the body, is particularly concentrated in cancer cells (2–10 mM). This concentration is approximately 1000 times that of normal cells, making GSH a specific tumor marker. Overexpression…
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Keywords:
gsh;
two photon;
redox;
tpef gsh ... See more keywords
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Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27441
Abstract: A rat model of tendon repair was established to investigate the effects of hydrogen water on tendon adhesion reduction. Thirty‐six Sprague Dawley rats were randomly divided into a normal saline (NS) group and a hydrogen…
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Keywords:
sod;
hydrogen;
group;
gsh ... See more keywords
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2
Published in 2022 at "Molecular Informatics"
DOI: 10.1002/minf.202200140
Abstract: A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active…
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Keywords:
dynamics simulations;
gsh;
role;
molecular dynamics ... See more keywords
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Published in 2018 at "NMR in Biomedicine"
DOI: 10.1002/nbm.3844
Abstract: The primary inhibitory neurotransmitter γ‐aminobutyric acid (GABA) and the major antioxidant glutathione (GSH) are compounds of high importance for the function and integrity of the human brain. In this study, a method for simultaneous J‐difference…
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Keywords:
suppressed hermes;
mega press;
gsh;
gaba ... See more keywords
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Published in 2020 at "Small"
DOI: 10.1002/smll.202002044
Abstract: Platinum (Pt) drugs are widely used in anti-cancer treatment although many reports advocated that tumor cells could inactivate Pt drugs via glutathione-Pt (GSH-Pt) adducts formation. To date, GSH chelated Pt molecules have not been assessed…
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Keywords:
cancer;
cancer treatment;
pt6 gs4;
gsh ... See more keywords
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Published in 2023 at "Small"
DOI: 10.1002/smll.202207825
Abstract: Nowadays, Fenton chemistry-based chemodynamic therapy (CDT) is an emerging approach to killing tumor cells by converting endogenous H2 O2 into cytotoxic hydroxyl radicals (·OH). However, the elimination of ·OH by intracellular overexpressed glutathione (GSH) results…
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Keywords:
gsh;
metal phenolic;
therapy;
phenolic networks ... See more keywords
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Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02793-4
Abstract: Paracetamol (acetaminophen, APAP) overdose is a leading cause of acute drug-induced liver failure. APAP hepatotoxicity is mediated by the reactive metabolite N-acetyl- p -benzoquinone imine (NAPQI). NAPQI is inactivated by conjugation with glutathione (GSH) to…
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Keywords:
apap cys;
cellular efflux;
apap;
gsh ... See more keywords
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Published in 2022 at "Applied microbiology and biotechnology"
DOI: 10.1007/s00253-022-11827-z
Abstract: Glutathione (GSH) is a metabolite that plays an important role in the fields of pharmacy, food, and cosmetics. Thus, it is necessary to increase its production to meet the demands. In this study, ScGSH1, ScGSH2,…
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Keywords:
pichia pastoris;
precursor feeding;
production;
synthesis gsh ... See more keywords
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Published in 2021 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-021-05074-7
Abstract: Bevacizumab (BEV) is a blocker of circulating VEGF A generation. However, BEV has adverse apoptotic and cytotoxic effects via upregulation of mitochondrial reactive oxygen species (ROS) and TRPM2 activation, and downregulation of cytosolic glutathione (GSH)…
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Keywords:
pigment epithelial;
treatment;
gsh;
bev ... See more keywords