Rapid screening and characterization of glutathione-trapped reactive metabolites using a polarity switch-based approach on a high-resolution quadrupole orbitrap mass spectrometer
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DOI: 10.1007/s00216-017-0814-8
Abstract: AbstractFormation of reactive metabolites that are capable to react with macromolecules could contribute to drug-induced toxicity. As part of early drug screening strategy to support small molecule structure-activity relationship analysis, glutathione (GSH) trapping is commonly… read more here.
Keywords: quadrupole orbitrap; mass; gsh conjugates; reactive metabolites ... See more keywords