Oral administration of γ-glutamylcysteine increases intracellular glutathione levels above homeostasis in a randomised human trial pilot study☆
Sign Up to like & getrecommendations! Published in 2017 at "Redox Biology"
DOI: 10.1016/j.redox.2017.01.014
Abstract: Objective To determine if orally dosed γ-glutamylcysteine (γ-GC) can increase cellular glutathione (GSH) levels above homeostasis. Many chronic and age-related disorders are associated with down-regulation, or impairment, of glutamate cysteine ligase (GCL). This suggests that… read more here.
Keywords: levels homeostasis; gsh levels; gsh; basal levels ... See more keywords
Thiol-Disulfide Exchange Reaction for Cellular Glutathione Detection with Surface-Enhanced Raman Scattering.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b01974
Abstract: Abnormal glutathione (GSH) levels are related to several diseases, including cancer. In this paper, surface-enhanced Raman spectroscopy (SERS) based on a 2-(pyridyldithio)ethylamine (PDEA)-modified AgNPs@Si wafer is proposed for intracellular GSH detection. PDEA plays multifunctional roles… read more here.
Keywords: surface enhanced; enhanced raman; gsh levels; thiol disulfide ... See more keywords
Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Nutrition"
DOI: 10.1038/ejcn.2017.132
Abstract: Background/Objectives:Glutathione (GSH) is the most abundant endogenous antioxidant and a critical regulator of oxidative stress. Maintenance of optimal tissues for GSH levels may be an important strategy for the prevention of oxidative stress-related diseases. We… read more here.
Keywords: administration; gsh levels; gsh; immune function ... See more keywords
Modulating the GSH/Trx selectivity of a fluorogenic disulfide-based thiol sensor to reveal diminished GSH levels under ER stress.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc04846k
Abstract: We synthesized a fluorogenic disulfide-based naphthalimide thiol probe (ER-Naph) with a hydrophilic endoplasmic reticulum (ER)-guiding glibenclamide unit. Its ER targeting ability and high selectivity to GSH over thioredoxin, a potent competitor, were clearly demonstrated, both… read more here.
Keywords: disulfide based; fluorogenic disulfide; gsh levels; gsh ... See more keywords