Orally Bioavailable Prodrugs of ψ-GSH: A Potential Treatment for Alzheimer's Disease.
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DOI: 10.1021/acs.jmedchem.2c00779
Abstract: Addressing glycation-induced oxidative stress in Alzheimer's disease (AD) is an emerging pharmacotherapeutic strategy. Restoration of the brain glyoxalase enzyme system that neutralizes reactive dicarbonyls is one such approach. Toward this end, we designed, synthesized, and… read more here.
Keywords: gsh potential; alzheimer disease; orally bioavailable; prodrugs gsh ... See more keywords