NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263
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DOI: 10.1158/1078-0432.ccr-18-0867
Abstract: Purpose: Effective targeted therapies are lacking for refractory and relapsed T-cell acute lymphoblastic leukemia (T-ALL). Suppression of the NOTCH pathway using gamma-secretase inhibitors (GSI) is toxic and clinically not effective. The goal of this study… read more here.
Keywords: abt 263; mcl levels; represses mcl; notch1 represses ... See more keywords