Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14954
Abstract: We have previously shown that treatment with a mGluR5 positive allosteric modulator (PAM) is neuroprotective after experimental traumatic brain injury (TBI), limiting post‐traumatic neuroinflammation by reducing pro‐inflammatory microglial activation and promoting anti‐inflammatory and neuroprotective responses.… read more here.
Keywords: anti inflammatory; creb signaling; akt gsk; gsk creb ... See more keywords
Cilostazol disrupts TLR-4, Akt/GSK-3β/CREB, and IL-6/JAK-2/STAT-3/SOCS-3 crosstalk in a rat model of Huntington's disease
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DOI: 10.1371/journal.pone.0203837
Abstract: Countless neurodegenerative diseases are associated with perverse multiple targets of cyclic nucleotide signalling, hastening neuronal death. Cilostazol, a phosphodiesterase-III inhibitor, exerts neuroprotective effects against sundry models of neurotoxicity, however, its role against Huntington’s disease (HD)… read more here.
Keywords: cilostazol; gsk creb; akt gsk;