Oncogenic KRAS sensitizes lung adenocarcinoma to GSK-J4-induced metabolic and oxidative stress.
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DOI: 10.1158/0008-5472.can-18-3511
Abstract: Genetic and epigenetic changes (e.g., histone methylation) contribute to cancer development and progression, but our understanding of whether and how specific mutations affect a cancer's sensitivity to histone demethylase (KDM) inhibitors is limited. Here, we… read more here.
Keywords: gsk; metabolic oxidative; oncogenic kras; cancer ... See more keywords