Biological evaluation and energetic analyses of novel GSK‐3β inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26522
Abstract: Glycogen synthase kinase‐3 beta (GSK‐3β) is involved in multiple signaling pathways. Consistent with its critical roles in normal cells, abnormalities in GSK‐3β activity have been implicated in diabetes, heart disease, Parkinson disease, and Alzheimer's disease.… read more here.
Keywords: biological evaluation; analyses novel; gsk inhibitors; evaluation energetic ... See more keywords
Receptor-based pharmacophore modeling, virtual screening, and molecular docking studies for the discovery of novel GSK-3β inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-019-4032-5
Abstract: AbstractConsidering the emerging importance of glycogen synthase kinase 3 beta (GSK-3β) inhibitors in treatment of Alzheimer’s disease, multi-protein structure receptor-based pharmacophore modeling was adopted to generate a 3D pharmacophore model for (GSK-3β) inhibitors. The generated… read more here.
Keywords: based pharmacophore; receptor based; molecular docking; pharmacophore modeling ... See more keywords
Portraying the selectivity of GSK-3 inhibitors towards CDK-2 by 3D similarity and molecular docking
Sign Up to like & getrecommendations! Published in 2018 at "Structural Chemistry"
DOI: 10.1007/s11224-018-1224-z
Abstract: The striking structural resemblance between adenosine triphosphate (ATP) binding sites of glycogen synthase kinase-3 (GSK-3) and cyclin-dependent kinase-2 (CDK-2) raises numerous off-target selectivity problems in lead-identification processes that may jeopardize their progress into safe and… read more here.
Keywords: similarity; portraying selectivity; molecular docking; selectivity ... See more keywords
Synthesis of benzimidazole-linked-1,3,4-oxadiazole carboxamides as GSK-3β inhibitors with in vivo antidepressant activity.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.01.040
Abstract: Recent findings of potential implications of glycogen synthase kinase-3β (GSK-3β) dysfunction in psychiatric disorders like depression, have increased focus for development of GSK-3β inhibitors with possible anti-depressant activity. Keeping this in view, we synthesized a… read more here.
Keywords: oxadiazole carboxamides; linked oxadiazole; benzimidazole linked; vivo antidepressant ... See more keywords
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.017
Abstract: The manuscript deals with the design, synthesis and biological evaluation of novel benzoxazinone-based and indole-based compounds as multifunctional neuroprotective agents. These compounds inhibit human adenosine kinase (hAK) and human glycogen synthase kinase 3 beta (hGSK-3β)… read more here.
Keywords: first dual; endowed antioxidant; dual gsk; gsk inhibitors ... See more keywords
Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-b]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00133
Abstract: Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that regulates numerous cellular processes, including metabolism, proliferation, and cell survival. Due to its multifaceted role, GSK-3 has been implicated in a variety of diseases, including Alzheimer's… read more here.
Keywords: gsk inhibitors; glycogen synthase; kinase gsk; synthase kinase ... See more keywords
Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00364
Abstract: Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that serves as an important regulator of a broad range of cellular functions. It has been linked to Alzheimer's disease as well as various other diseases, including… read more here.
Keywords: gsk inhibitors; glycogen synthase; kinase; kinase gsk ... See more keywords
Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3β Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00520
Abstract: Development of glycogen synthase kinase-3β (GSK-3β) inactivation-centric agents with ploypharmacological profiles is increasingly recognized as a promising therapeutic strategy against the multifactorial etiopathology of Alzheimer's disease (AD). In this respect, a series of disubstituted aminopyrazole… read more here.
Keywords: inflammation; oxidative neurotoxicity; gsk inhibitors; development ... See more keywords
Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015)
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2017.1259412
Abstract: ABSTRACT Introduction: Glycogen synthase kinase (GSK-3) is a serine/threonine kinase that phosphorylates more than one hundred different sequences within proteins in a variety of different pathways. It is a key component of a remarkably large… read more here.
Keywords: glycogen synthase; kinase gsk; synthase kinase; gsk inhibitors ... See more keywords
GSK-3 Inhibitors in Regulation and Controlling of Colon Carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Current drug targets"
DOI: 10.2174/1389450122666210204203950
Abstract: BACKGROUND GSK-3 inhibitors became a novel therapeutic agent treating cancer. There are so many uses of GSK-3 inhibitor for treating cancer like breast cancer, lung cancer, gastric cancer, and no pathological changes are shown by… read more here.
Keywords: gsk inhibitors; colon carcinoma; cancer;
Corrigendum to: GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug targets"
DOI: 10.2174/138945012311220720160340
Abstract: The author requested to add a co-author after the publication of the original article [1]. In this correction, the author has been added in the article entitled "GSK-3 Inhibitors in the Regulation and Control of… read more here.
Keywords: inhibitors regulation; university; gsk inhibitors; physics ... See more keywords