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   Articles with "gsk3" as a keyword



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Apoptotic and antihepatofibrotic effect of honokiol via activation of GSK3β and suppression of Wnt/β‐catenin pathway in hepatic stellate cells

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recommendations! Published in 2020 at "Phytotherapy Research"

DOI: 10.1002/ptr.6824

Abstract: Though honokiol, derived from the Magnolia tree, was known to suppress renal fibrosis, pulmonary fibrosis, non‐alcoholic steatoheptitis, inflammation and cancers, the underlying antifibrotic mechanisms of honokiol are not fully understood in hepatic stellate cells until… read more here.

Keywords: catenin; hepatic stellate; honokiol; gsk3 ... See more keywords
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GSK3β Controls mTOR and Prosurvival Signaling in Neurons

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recommendations! Published in 2017 at "Molecular Neurobiology"

DOI: 10.1007/s12035-017-0823-9

Abstract: Glycogen synthase kinases-3β (GSK3β) is a key regulator of cell homeostasis. In neurons, GSK3β contributes to control of neuronal transmission and plasticity. Despite extensive studies in non-neuronal cells, crosstalk between GSK3β and other signaling pathways… read more here.

Keywords: prosurvival signaling; neurons gsk3; mtor; gsk3 controls ... See more keywords
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Regulation of GSK3β by Ser389 Phosphorylation During Neural Development

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recommendations! Published in 2020 at "Molecular Neurobiology"

DOI: 10.1007/s12035-020-02147-2

Abstract: GSK3β is a constitutively active kinase that promotes cell death, which requires strict regulatory mechanisms. Although Akt-mediated phosphorylation at Ser 9 is the default mechanism to inactivate GSK3β, phosphorylation of GSK3β at Ser 389 by… read more here.

Keywords: phosphorylation gsk3; gsk3; ser 389; brain ... See more keywords
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Silencing GSK3β instead of DKK1 can inhibit osteogenic differentiation caused by co-exposure to fluoride and arsenic.

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recommendations! Published in 2019 at "Bone"

DOI: 10.1016/j.bone.2019.03.016

Abstract: Chronic exposure to combined fluoride (F) and arsenic (As) continues to be a major public health problem worldwide, attracting the attention of an increasing number of researchers. While bone is the main target organ of… read more here.

Keywords: catenin; dkk1; osteogenic differentiation; fluoride arsenic ... See more keywords
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Neuroprotective effect of breviscapine on traumatic brain injury in rats associated with the inhibition of GSK3β signaling pathway

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recommendations! Published in 2017 at "Brain Research"

DOI: 10.1016/j.brainres.2017.01.031

Abstract: Breviscapine, a standardized Chinese herbal medicine extracted from Erigeron breviscapine, has been widely used to treat cerebrovascular diseases. However, there are no reports about the neuroprotective effects and underlying molecular mechanisms of breviscapine on traumatic… read more here.

Keywords: traumatic brain; breviscapine; brain injury; brain ... See more keywords
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CRMP2 mediates GSK3β actions in the striatum on regulating neuronal structure and mania-like behavior.

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recommendations! Published in 2019 at "Journal of affective disorders"

DOI: 10.1016/j.jad.2018.10.371

Abstract: BACKGROUND Genetic and physiological studies have implicated the striatum in bipolar disorder (BD). Although Glycogen synthase kinase 3 beta (GSK3β) has been suggested to play a role in the pathophysiology of BD since it is… read more here.

Keywords: mania like; crmp2; like behavior; structure ... See more keywords

GSK3 and its interactions with the PI3K/AKT/mTOR signalling network.

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recommendations! Published in 2017 at "Advances in biological regulation"

DOI: 10.1016/j.jbior.2017.06.003

Abstract: Glycogen Synthase Kinase-3 (GSK3 or GSK-3) is a promiscuous protein kinase and its phosphorylation of its diverse substrates has major influences on many areas of physiology and pathology, including cellular metabolism, lineage commitment and neuroscience.… read more here.

Keywords: phosphorylation; pi3k akt; gsk3; mtor signalling ... See more keywords
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Dose-dependent effects of isoflurane on TrkB and GSK3β signaling: importance of burst suppression pattern

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recommendations! Published in 2018 at "Neuroscience letters"

DOI: 10.1016/j.neulet.2018.11.018

Abstract: OBJECTIVES Deep burst-suppressing isoflurane anesthesia regulates signaling pathways connected with antidepressant responses in the rodent brain: activation of TrkB neurotrophin receptor and inhibition of GSK3β kinase (glycogen synthase kinase 3β). The main objective of this… read more here.

Keywords: gsk3; gsk3 signaling; burst suppression; trkb gsk3 ... See more keywords
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Protective role of metformin against methamphetamine induced anxiety, depression, cognition impairment and neurodegeneration in rat: The role of CREB/BDNF and Akt/GSK3 signaling pathways.

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recommendations! Published in 2019 at "Neurotoxicology"

DOI: 10.1016/j.neuro.2019.02.004

Abstract: BACKGROUND Methamphetamine is a neuro-stimulant with neurodegenerative effects, and ambiguous mechanism of action. Metformin is an antidiabetic agent with neuroprotective properties but not fully understood mechanisms. The present study investigated the molecular basis of metformin… read more here.

Keywords: methamphetamine; methamphetamine induced; bdnf akt; role ... See more keywords
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Stressed and Inflamed, Can GSK3 Be Blamed?

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recommendations! Published in 2017 at "Trends in biochemical sciences"

DOI: 10.1016/j.tibs.2016.10.009

Abstract: Psychological stress has a pervasive influence on our lives. In many cases adapting to stress strengthens organisms, but chronic or severe stress is usually harmful. One surprising outcome of psychological stress is the activation of… read more here.

Keywords: stressed inflamed; inflammation; stress; inflamed gsk3 ... See more keywords

Phosphorus Overload Promotes Hepatic Lipolysis by Suppressing GSK3β-Dependent Phosphorylation of PPARα at Ser84 and Thr265 in a Freshwater Teleost.

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recommendations! Published in 2023 at "Environmental science & technology"

DOI: 10.1021/acs.est.2c06330

Abstract: Excessive phosphorus (Pi) contributes to eutrophication in an aquatic environment, which threatens human and fish health. However, the mechanisms by which Pi overload influences aquatic animals remain largely unexplored. In the present study, Pi supplementation… read more here.

Keywords: phosphorus; lipolysis; gsk3; phosphorylation ... See more keywords