Activation of GSK3&bgr;/&bgr;‐TrCP axis via PHLPP1 exacerbates Nrf2 degradation leading to impairment in cell survival pathway during diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.550
Abstract: ABSTRACT NF‐E2 p45‐related factor 2 (Nrf2), is a major redox sensitive transcription factor that plays an essential role in regulating glucose metabolism. Inactivation of Nrf2 has been associated with diabetic complications however, mechanisms warranting Nrf2… read more here.
Keywords: bgr trcp; bgr; phlpp1; gsk3 bgr ... See more keywords
Anti‐apoptotic effect of Suxiao Jiuxin Pills against hypoxia‐induced injury through PI3K/Akt/GSK3&bgr; pathway in HL‐1 cardiomyocytes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Chinese Medical Association"
DOI: 10.1016/j.jcma.2018.02.002
Abstract: Background: Suxiao Jiuxin Pill (SX), Chinese traditional medicine primarily consisting of tetramethylpyrazine and borneol, has been shown to protect against ischemic heart diseases. Nevertheless, the involved mechanism still remains unclear. The following study aimed to… read more here.
Keywords: akt; pi3k; effect; gsk3 bgr ... See more keywords
Minocycline protects developing brain against ethanol-induced damage
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.11.019
Abstract: ABSTRACT Fetal alcohol spectrum disorders (FASD) are caused by ethanol exposure during the pregnancy and is the leading cause of mental retardation. Ethanol exposure during the development results in the loss of neurons in the… read more here.
Keywords: minocycline; developing brain; activation; gsk3 bgr ... See more keywords
Mitochondrial Dysfunction and Apoptosis Are Attenuated on &kgr;-Opioid Receptor Activation Through AMPK/GSK-3&bgr; Pathway After Myocardial Ischemia and Reperfusion
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000635
Abstract: Abstract: Previous studies have shown that &kgr;-opioid receptor activation possesses cardioprotection against myocardial ischemia and reperfusion (MI/R) injury. The current study was designed to investigate whether mitochondrial dysfunction after MI/R is regulated by the &kgr;-opioid… read more here.
Keywords: kgr opioid; activation; opioid receptor; gsk3 bgr ... See more keywords
Unravelling the GSK3&bgr;-related genotypic interaction network influencing hippocampal volume in recurrent major depressive disorder
Sign Up to like & getrecommendations! Published in 2018 at "Psychiatric Genetics"
DOI: 10.1097/ypg.0000000000000203
Abstract: Objective Glycogen synthase kinase 3&bgr; (GSK3&bgr;) has been implicated in mood disorders. We previously reported associations between a GSK3&bgr; polymorphism and hippocampal volume in major depressive disorder (MDD). We then reported similar associations for a… read more here.
Keywords: major depressive; hippocampal volume; depressive disorder; gsk3 bgr ... See more keywords