GSK3β inhibition restores cortical gamma oscillation and cognitive behavior in a mouse model of NMDA receptor hypofunction relevant to schizophrenia
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-00819-0
Abstract: Cortical gamma oscillations are believed to be involved in mental processes which are disturbed in schizophrenia. For example, the magnitudes of sensory-evoked oscillations, as measured by auditory steady-state responses (ASSRs) at 40 Hz, are robustly diminished,… read more here.
Keywords: cortical gamma; gamma; gamma oscillations; gsk3 inhibition ... See more keywords
GSK3β inhibition attenuates LPS-induced IL-6 expression in porcine adipocytes
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34186-0
Abstract: IL-6 is not only a proinflammatory cytokine associated with inflammatory responses but also a regulator on the energy and glucose metabolism in adipose tissue. Glycogen synthase kinase 3β (GSK3β) has fundamental roles in the regulation… read more here.
Keywords: lps induced; activity; porcine; gsk3 inhibition ... See more keywords
GSK3β Inhibition Prevents Macrophage Reprogramming by High-Dose Methotrexate.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of innate immunity"
DOI: 10.1159/000526622
Abstract: Methotrexate (MTX) is an antifolate drug used as a chemotherapeutic agent for acute lymphoblastic leukemia, where MTX improves patients' prognosis. Macrophage reprogramming is being increasingly assessed as an antitumor therapeutic strategy. However, and although MTX… read more here.
Keywords: macrophage reprogramming; macrophage; gsk3 inhibition; methotrexate ... See more keywords