AKT/GSK3β/NFATc1 and ROS signal axes are involved in AZD1390-mediated inhibitory effects on osteoclast and OVX-induced osteoporosis.
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DOI: 10.2139/ssrn.4071617
Abstract: As a common disease in modern society, osteoporosis is caused by osteoclast hyperactivation, leading to enhanced bone resorption. Reactive oxygen species (ROS) metobolism and nuclear factor-activated T cells 1 (NFATc1) activities are two crucial processes… read more here.
Keywords: gsk3 nfatc1; akt gsk3; ovx induced; ros scavenging ... See more keywords