GSK3β-SCFFBXW7α mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover
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DOI: 10.1093/nar/gkz163
Abstract: Abstract IRF1 (Interferon Regulatory Factor-1) is the prototype of the IRF family of DNA binding transcription factors. IRF1 protein expression is regulated by transient up-regulation in response to external stimuli followed by rapid degradation via… read more here.
Keywords: transcription; scffbxw7 mediated; turnover; gsk3 scffbxw7 ... See more keywords