Phospholipase D2 Regulates Microtubule Acetylation by Modulating Gsk3β‐Tau Signaling in Mouse Oocytes During Meiotic Maturation
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DOI: 10.1002/mrd.70051
Abstract: Phospholipase D2 (PLD2) modulates cytoskeletal dynamics and membrane trafficking processes by converting phosphatidylcholine (PC) into phosphatidic acid (PA) and choline within somatic cells. Nonetheless, the role in oocyte meiosis remains largely unknown. Here, we demonstrate… read more here.
Keywords: pld2; tau; gsk3 tau; mouse oocytes ... See more keywords
The Interplay between GSK3β and Tau Ser262 Phosphorylation during the Progression of Tau Pathology
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DOI: 10.3390/ijms231911610
Abstract: Tau hyperphosphorylation has been linked directly to the formation of toxic neurofibrillary tangles (NFTs) in tauopathies, however, prior to NFT formation, the sequence of pathological events involving tau phosphorylation remains unclear. Here, the effect of… read more here.
Keywords: gsk3 tau; tau; pathology; tau pathology ... See more keywords
Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity
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DOI: 10.3390/ph15040426
Abstract: The inhibition of glycogen synthase kinase 3β (GSK3β) activity through pharmacological intervention represents a promising approach for treating challenging neurodegenerative disorders like Alzheimer’s disease. Similarly, abnormal tau aggregate accumulation in neurons is a hallmark of… read more here.
Keywords: tau; activity; gsk3 tau; gsk3 ... See more keywords