Unusually High Affinity of the PLK Inhibitors RO3280 and GSK461364 to HSA and Its Possible Pharmacokinetic Implications
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DOI: 10.1021/acs.molpharmaceut.2c00849
Abstract: The binding processes of two Polo-like kinase inhibitors, RO3280 and GSK461364, to the human serum albumin (HSA) protein as well as the protonation equilibria of both compounds have been studied combining absorbance and fluorescence spectroscopy… read more here.
Keywords: gsk461364 hsa; inhibitors ro3280; high affinity; ro3280 gsk461364 ... See more keywords