GsMTx4-D provides protection to the D2.mdx mouse
Sign Up to like & getrecommendations! Published in 2018 at "Neuromuscular Disorders"
DOI: 10.1016/j.nmd.2018.07.005
Abstract: Duchenne muscular dystrophy is a life-limiting muscle disease that has no current effective therapy. Despite mounting evidence that dysregulation of mechanosensitive ion channels is a significant contributor to dystrophy pathogenesis, effective pharmacologic strategies targeting these… read more here.
Keywords: gsmtx4; muscle; mdx mouse; mouse gsmtx4 ... See more keywords
Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology.
Sign Up to like & getrecommendations! Published in 2017 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2017.07.011
Abstract: Discovery of Piezo channels and the reporting of their sensitivity to the inhibitor GsMTx4 were important milestones in the study of non-selective cationic mechanosensitive channels (MSCs) in normal physiology and pathogenesis. GsMTx4 had been used… read more here.
Keywords: piezo channels; muscle; piezo; pathology ... See more keywords