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   Articles with "gstm1" as a keyword



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Influence of functional variants Asp312Asn and Lys751Gln of Xeroderma Pigmentosum Group D (XPD) and Glutathione S‐transferase Mu 1 (GSTM1) and Theta 1 (GSTT1) genes on cutaneous melanoma susceptibility and prognosis

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recommendations! Published in 2019 at "Experimental Dermatology"

DOI: 10.1111/exd.13914

Abstract: We aimed to evaluate whether variants in repair (XPD Asp312Asn, XPD Lys751Gln) and detoxification (GSTM1, GSTT1) genes alter risk, clinicopathological aspects and survival of cutaneous melanoma (CM). Genotyping was performed in 229 CM patients and… read more here.

Keywords: gstm1; plus gstt1; cutaneous melanoma; gstt1 ... See more keywords
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MicroRNA-423-5p facilitates hypoxia/reoxygenation-induced apoptosis in renal proximal tubular epithelial cells by targeting GSTM1 via endoplasmic reticulum stress.

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recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.18289

Abstract: It has been reported that microRNAs (miRs) can regulate renal response to acute injury and members of them are believed to be important in maintenance of renal function and development of renal injury. We investigated… read more here.

Keywords: gstm1; hypoxia reoxygenation; microrna 423; mir 423 ... See more keywords
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Comprehensive analysis of the correlation between GSTM1 and tumor immunity in colon cancer

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recommendations! Published in 2022 at "Journal of Gastrointestinal Oncology"

DOI: 10.21037/jgo-22-1060

Abstract: Background Glutathione S-transferase mu 1 (GSTM1) is one of the major glutathione conjugation enzymes. Its expression and activity have been suggested to correlate with the occurrence of colon cancer; however, the role of GSTM1 in… read more here.

Keywords: tumor immunity; gstm1; analysis; gstm1 tumor ... See more keywords

Impact of GSTT1 and GSTM1 Polymorphisms in the Susceptibility to Philadelphia Negative Chronic Myeloid Leukaemia.

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recommendations! Published in 2022 at "Current cancer drug targets"

DOI: 10.2174/1568009623666221027103845

Abstract: The objective of our research was to clarify the role of genetic polymorphisms in GST (T1 and M1) in the development of Ph-ve CML. MATERIALS AND METHODS We report on a case-control study, with 126… read more here.

Keywords: impact gstt1; statistically significant; gstm1; gstt1 gstm1 ... See more keywords
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The Catalytic Activity of GSTM1 In vitro is Independent of MAPK8.

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recommendations! Published in 2021 at "Drug metabolism letters"

DOI: 10.2174/1872312814666211122164456

Abstract: BACKGROUND Glutathione S-transferases (GSTs) are phase II metabolic enzymes crucial for the metabolism of electrophilic drugs. Additionally, several GST isoforms are involved in protein- protein interaction with mitogen-activated protein kinases (MAPKs), modulating apoptosis pathways. METHODS… read more here.

Keywords: gstm1; activity gstm1; activity; catalytic activity ... See more keywords
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The Association of GSTT1, GSTM1, and TNF-α Polymorphisms With the Risk and Outcome in Multiple Myeloma

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recommendations! Published in 2019 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2019.01056

Abstract: Oxidative stress and systemic inflammation are closely linked with increased risk of cancer development. Tumor necrosis factor alpha (TNF-α) is one of the pro-inflammatory cytokines. Glutathione S-transferases (GSTs) are enzymes involved in oxidative stress handling.… read more here.

Keywords: risk; gstm1; gstt1 gstm1; risk outcome ... See more keywords
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Desloratadine Efficacy in Relation to GSTM1 and GSTT1 Polymorphic Genes in Chronic Spontaneous Urticaria

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recommendations! Published in 2022 at "Indian Journal of Dermatology"

DOI: 10.4103/ijd.ijd_546_17

Abstract: Background: The etiopathogeny of chronic spontaneous urticaria (CSU) is not well defined. Allelism in glutathione S-transferase GSTM1 and GSTT1 has been suggested as a risk factor. Desloratadine is the first-line treatment for this disease. Objective:… read more here.

Keywords: desloratadine; efficacy; treatment; gstm1 ... See more keywords